Evidence map›Paper›PMID 33478555›Full record

ArticleMolecular brain2021

Non-SUMOylated CRMP2 decreases Na

Kimberly Gomez, Dongzhi Ran, Cynthia L Madura, Aubin Moutal, Rajesh Khanna

Open access · goldAbstract read
In one paragraph

Article in Molecular brain, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. SUMOylation and Major Depressive Disorder.International journal of molecular sciences · 2022
    Review
  12. Article
  13. Article
  14. Mechanisms Underlying the Selective Therapeutic Efficacy of Carbamazepine for Attenuation of Trigeminal Nerve Injury Pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  15. Review
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kimberly Gomez *Department of Pharmacology, College of Medicine, University of Arizona, 1501 North Campbell Drive, P.O. Box 245050, Tucson, AZ, 85724, USA.
Dongzhi Ran *Department of Pharmacology, College of Medicine, University of Arizona, 1501 North Campbell Drive, P.O. Box 245050, Tucson, AZ, 85724, USA.
Cynthia L MaduraDepartment of Pharmacology, College of Medicine, University of Arizona, 1501 North Campbell Drive, P.O. Box 245050, Tucson, AZ, 85724, USA.
Aubin MoutalDepartment of Pharmacology, College of Medicine, University of Arizona, 1501 North Campbell Drive, P.O. Box 245050, Tucson, AZ, 85724, USA.
Rajesh KhannaDepartment of Pharmacology, College of Medicine, University of Arizona, 1501 North Campbell Drive, P.O. Box 245050, Tucson, AZ, 85724, USA. rkhanna@arizona.edu.ORCID 0000-0002-9066-2969
University of Arizona · US

Funding

CRMP2, mitochondria, and Huntington’s diseaseR01NS098772 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI BRUSTOVETSKY, NICKOLAY, KHANNA, RAJESH · 2017 to 2021
$2.8M
Sentrin proteases, CRMP2 deSUMOylation, and Chronic PainR01NS120663 · NINDS · UNIVERSITY OF FLORIDA · PI KHANNA, RAJESH · 2020 to 2021
$2.6M
CRMP2, Nav1.7 sodium channel, and chronic painR01DA042852 · NIDA · UNIVERSITY OF ARIZONA · PI KHANNA, RAJESH · 2017 to 2021
$1.9M
6 · The paper itself

Abstract

Voltage-gated sodium channels are key players in neuronal excitability and pain signaling. Functional expression of the voltage-gated sodium channel Na

Indexed as

EndocytosisSumoylationAdaptor Proteins, Signal TransducingAnimalsClathrinFemaleGanglia, SpinalGene SilencingHyperalgesiaIntercellular Signaling Peptides and ProteinsIon Channel GatingMaleMembrane ProteinsMiceModels, BiologicalNAV1.7 Voltage-Gated Sodium ChannelAdaptor Proteins, Signal TransducingClathrincollapsin response mediator protein-2Eps15 protein, mouseIntercellular Signaling Peptides and ProteinsMembrane ProteinsNAV1.7 Voltage-Gated Sodium ChannelNedd4l protein, mouseNedd4 Ubiquitin Protein LigasesNerve Tissue ProteinsNumb protein, mousepitstop 2Scn9a protein, mouseSulfonamidesThiazolidinesCRMP2EndocytosisEps15NaV1.7Nedd4-2Neuropathic painNumbSumoylation

Identifiers

PMID33478555
PMCPMC7819318
OpenAlexW3126032609

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.