ArticleJournal of biological engineering2021
3D printed Ti6Al4V bone scaffolds with different pore structure effects on bone ingrowth.
Article in Journal of biological engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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The trial behind it
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Who cites it
46 citing papers in PubMed.
- Sequential Regulation of Neurovascular Bone Regeneration in Large Bone Defects Using Black Phosphorus-Europium Nanosheet Integrated TPMS Biomimetic Scaffold with Photo-Controlled Ion Release.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Elastic Properties of Reinforced Body-Centered Cubic Lattice Structures.Materials (Basel, Switzerland) · 2026Article
- 3D-Printed PLA/HA Composite Scaffolds: Balancing Mechanical Properties for Bone Tissue Engineering.Materials (Basel, Switzerland) · 2026Article
- Metallic topological structures in bone repair implants: Design, properties, and biological interactions.Journal of orthopaedic translation · 2026Review
- Biomechanical evaluation of 3D-printed porous lattice versus solid mandibular implants: an in vitro study.Scientific reports · 2026Article
- 3D-Printed Titanium Implants with Bioactive Peptide-Polysaccharide Scaffolds for Personalized Bone Reconstruction.Advanced healthcare materials · 2026Article
- Functional personalization in digital manufacturing: a translational framework for patient-specific implants, arthroscopic locators, and therapeutic constructs.Frontiers in bioengineering and biotechnology · 2026Article
- Evaluation of bone formation within β-tricalcium phosphate scaffolds in a sheep scapular bioreactor model using micro-computed tomography analysis.Regenerative biomaterials · 2026Article
- RefinedFrontiers in bioengineering and biotechnology · 2026Article
- Research progress on osseointegration performance of porous structure-modified titanium alloy implants.Frontiers in bioengineering and biotechnology · 2026Review
- Optimizing mandibular bone defect reconstruction using adipose-derived stem cells on 3-dimensionally printed polycaprolactone/xenograft scaffolds in canine model.BMC oral health · 2025Article
- Synergistic Advances in Additive Manufacturing and Surface Engineering for Polymeric Biomedical Devices.ACS polymers Au · 2025Review
- Advances in Titanium-Based Biomaterial for Human Bone Scaffolds: Narrative Review on Design, Fabrication, Surface Engineering, Implantation, and Biological Evaluation.Materials (Basel, Switzerland) · 2025Review
- Advances in Molecularly Imprinted Polymers for Bone Biomarker Detection and Therapeutic Applications.ChemistryOpen · 2025Review
- [Biocompatibility of 3D printed biodegradable WE43 magnesium alloy scaffolds and treatment of bone defects].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2025Article
- Spatially distributed and interconnected porous architectures for dental implants.International journal of implant dentistry · 2025Article
- Investigation of Friction for Nanocoated and Uncoated Ti-6Al-4V Substrates via the Modified Pin-on-Disk Technique for Transfemoral Implants.Journal of biomedical physics & engineering · 2025Article
- Microporous annealed particle hydrogels in cell culture, tissue regeneration, and emerging application in cancer immunotherapy.American journal of cancer research · 2025Review
- Biomimetic multizonal scaffolds for the reconstruction of zonal articular cartilage in chondral and osteochondral defects.Bioactive materials · 2025Review
- Bone Ingrowth Simulation Within the Hexanoid, a Novel Scaffold Design.3D printing and additive manufacturing · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The microstructure of porous scaffolds plays a vital role in bone regeneration, but its optimal shape is still unclear. In this study, four kinds of porous titanium alloy scaffolds with similar porosities (65%) and pore sizes (650 μm) and different structures were prepared by selective laser melting. Four scaffolds were implanted into the distal femur of rabbits to evaluate bone tissue growth in vivo. Micro-CT and hard tissue section analyses were performed 6 and 12 weeks after the operation to reveal the bone growth of the porous scaffold. The results show that diamond lattice unit (DIA) bone growth is the best of the four topological scaffolds. Through computational fluid dynamics (CFD) analysis, the permeability, velocity and flow trajectory inside the scaffold structure were calculated. The internal fluid velocity difference of the DIA structure is the smallest, and the trajectory of fluid flow inside the scaffold is the longest, which is beneficial for blood vessel growth, nutrient transport and bone formation. In this study, the mechanism of bone growth in different structures was revealed by in vivo experiments combined with CFD, providing a new theoretical basis for the design of bone scaffolds in the future.
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