ArticleBMC biology2021
DNA methyltransferase 3a mediates developmental thermal plasticity.
Article in BMC biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
- Microbiome-Epigenome Interplay Impacts Microbial Symbiosis and Stress Adaptations in the Brown Planthopper (International journal of molecular sciences · 2026Article
- Cooperative care influences genome-wide levels of DNA methylation in nestling chestnut-crowned babblers.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Article
- Contrasting epigenetics of Ixodes scapularis populations.Scientific reports · 2026Article
- Embryonic Hormetic Priming Modulates Later-Life Thermal Tolerance.Ecology and evolution · 2026Article
- DNA Methylation-Associated Epigenetic Changes in Thermotolerance ofInternational journal of molecular sciences · 2025Article
- Network architecture of transcriptomic stress responses in zebrafish embryos.PLoS computational biology · 2025Article
- A user's guide for understanding reptile and amphibian hydroregulation and climate change impacts.Conservation physiology · 2025Article
- Genomic and Epigenomic Influences on Resilience across Scales: Lessons from the Responses of Fish to Environmental Stressors.Integrative and comparative biology · 2024Review
- Epigenetics Research in Evolutionary Biology: Perspectives on Timescales and Mechanisms.Molecular biology and evolution · 2024Review
- Epigenetics and environmental health.Frontiers of medicine · 2024Review
- Thyroid hormone links environmental signals to DNA methylation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Intergenerational plasticity aligns with temperature-dependent selection on offspring metabolic rates.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Potential Role of DNA Methylation as a Driver of Plastic Responses to the Environment Across Cells, Organisms, and Populations.Genome biology and evolution · 2024Article
- Plasticity and associated epigenetic mechanisms play a role in thermal evolution during range expansion.Evolution letters · 2024Article
- Epigenetic Diversity Underlying Seasonal and Annual Variations in Brown Planthopper (BPH) Populations as Revealed by Methylation- sensitive Restriction Assay.Current genomics · 2023Article
- Associations between DNA methylation and gene regulation depend on chromatin accessibility during transgenerational plasticity.BMC biology · 2023Article
- Experimental DNA Demethylation Reduces Expression Plasticity and Thermal Tolerance in Pacific Oysters.Marine biotechnology (New York, N.Y.) · 2023Article
- Review
- How can physiology best contribute to wildlife conservation in a warming world?Conservation physiology · 2023Article
- Genetic and epigenetic regulation of growth, reproduction, disease resistance and stress responses in aquaculture.Frontiers in genetics · 2022Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThermal plasticity is pivotal for evolution in changing climates and in mediating resilience to its potentially negative effects. The efficacy to respond to environmental change depends on underlying mechanisms. DNA methylation induced by DNA methyltransferase 3 enzymes in the germline or during early embryonic development may be correlated with responses to environmental change. This developmental plasticity can interact with reversible acclimation within adult organisms, which would increase the speed of response and could alleviate potential mismatches between parental or early embryonic environments and those experienced at later life stages. Our aim was to determine whether there is a causative relationship between DNMT3 enzyme and developmental thermal plasticity and whether either or both interact with short-term acclimation to alter fitness and thermal responses in zebrafish (Danio rerio).
resultsWe developed a novel DNMT3a knock-out model to show that sequential knock-out of DNA methyltransferase 3a isoforms (DNMT3aa
conclusionsOur results show that DNMT3a regulates developmental thermal plasticity and that the phenotypic effects of different DNMT3a isoforms are additive. However, DNMT3a interacts with other mechanisms, such as histone (de)acetylation, induced during short-term acclimation to buffer phenotypes from environmental change. Interactions between these mechanisms make phenotypic compensation for climate change more efficient and make it less likely that thermal plasticity incurs a cost resulting from environmental mismatches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.