Evidence map›Paper›PMID 33478376›Full record

ArticleInternational journal of stroke : official journal of the International Stroke Society2021

Cortical superficial siderosis in the general population: The Framingham Heart and Rotterdam studies.

Ashkan Shoamanesh, Saloua Akoudad, Jayandra J Himali, Alexa S Beiser, Charles DeCarli, Sudha Seshadri, M Arfan Ikram, Jose R Romero, Meike W Vernooij

Open access · greenAbstract read
In one paragraph

Article in International journal of stroke : official journal of the International Stroke Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Observational
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Vascular Cognitive Impairment (VCI).Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Ashkan ShoamaneshPopulation Health Research Institute, McMaster University, Hamilton, ON, Canada.ORCID 0000-0002-2802-1626
Saloua AkoudadErasmus MC, Rotterdam, The Netherlands.
Jayandra J HimaliBoston University School of Medicine, Boston, MA, USA.
Alexa S BeiserBoston University School of Medicine, Boston, MA, USA.
Charles DeCarliDavis School of Medicine, University of California, Sacramento, CA, USA.
Sudha SeshadriBoston University School of Medicine, Boston, MA, USA.
M Arfan IkramErasmus MC, Rotterdam, The Netherlands.
Jose R RomeroBoston University School of Medicine, Boston, MA, USA.
Meike W VernooijErasmus MC, Rotterdam, The Netherlands.
Erasmus MC · NLBoston University · USPopulation Health Research Institute · CAThe University of Texas Health Science Center at San Antonio · USUniversity of California, Davis · US

Funding

UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI OLICHNEY, JOHN M · 1991 to 2020
$28.3M
PRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9M
EPIDEMIOLOGY OF DEMENTIA IN THE FRAMINGHAM STUDYR01AG008122 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, SESHADRI, SUDHA · 1989 to 2015
$14.4M
MRI, Genetics &Cognitive Precursors of AD &DementiaR01AG016495 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA · 1999 to 2016
$12.5M
Collaborative GWAS of Dementia, AD and related MRI and Cognitive EndophenotypesR01AG033193 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI SESHADRI, SUDHA · 2009 to 2016
$4.4M
Framingham: Inflammation, Genes &Cardiovascular DiseaseR01HL076784 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J. · 2004 to 2008
$3.9M
Aging and Inflammation: Longitudinal Markers and Genetics in the Framingham StudyR01AG028321 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J. · 2006 to 2010
$1.8M
Ventricular Matrix Remodeling: Correlates and PrognosisR01HL067288 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN S. · 2001 to 2004
$870k
ASYMPTOMATIC LEFT VENTRICULAR DYSFUNCTIONK24HL004334 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN S · 2001 to 2008
$707k
Risk Factors, Genetics and Cognition in Cerebral Microbleeds: Framingham StudyK23AG038444 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROMERO, JOSE RAFAEL · 2011 to 2015
$644k
Cerebral Microbleeds in Young Adults: risk factors, biomarkers and geneticsR03AG048180 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROMERO, JOSE RAFAEL · 2015 to 2016
$164k
THE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–
NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS K24 HL004334NHLBI NIH HHS N01 HC025195NHLBI NIH HHS R01 HL067288NHLBI NIH HHS R01 HL076784NIA NIH HHS K23 AG038444NIA NIH HHS P30 AG010129NIA NIH HHS R01 AG008122NIA NIH HHS R01 AG016495NIA NIH HHS R01 AG028321NIA NIH HHS R01 AG033193NIA NIH HHS R03 AG048180NINDS NIH HHS R01 NS017950
6 · The paper itself

Abstract

objectiveWe aimed to characterize cortical superficial siderosis, its determinants and sequel, in community-dwelling older adults.

methodsThe sample consisted of Framingham (

resultsAmong a total of 6049 participants, 4846 did not have any microbleeds or cortical superficial siderosis (80%), 401 had deep/mixed microbleeds (6.6%), 776 had strictly lobar microbleeds without cortical superficial siderosis (12.8%) and 26 had cortical superficial siderosis with/without microbleeds (0.43%). In comparison to participants without microbleeds or cortical superficial siderosis and to those with strictly lobar microbleeds but without cortical superficial siderosis, participants with cortical superficial siderosis were older (OR 1.09 per year, 95% CI 1.05, 1.14;

conclusionOur study adds supporting evidence to the association between cortical superficial siderosis and cerebral amyloid angiopathy within the general population. Community-dwelling persons with cortical superficial siderosis may be at high risk for intracerebral hemorrhage and future neurological events.

Indexed as

Cerebral Amyloid AngiopathySiderosisStrokeAgedCerebral HemorrhageHumansLongitudinal StudiesMagnetic Resonance ImagingBrain microbleedscerebral amyloid angiopathycerebral hemorrhagecommunitycortical superficial siderosisstroke facilities

Identifiers

PMID33478376
PMCPMC9822782
OpenAlexW3123288843

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.