Evidence map›Paper›PMID 33478337›Full record

ArticleJournal of dental research2021

Antiresorptive-Type and Discontinuation-Timing Affect ONJ Burden.

D Hadaya, A Soundia, I Gkouveris, O Bezouglaia, S M Dry, F Q Pirih, T L Aghaloo, S Tetradis

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. [Expert consensus on perioperative management of tooth extraction in patients receiving denosumab therapy].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

D HadayaDivision of Diagnostic and Surgical Sciences, UCLA School of Dentistry, Los Angeles, CA, USA.
A SoundiaDivision of Diagnostic and Surgical Sciences, UCLA School of Dentistry, Los Angeles, CA, USA.
I GkouverisDivision of Diagnostic and Surgical Sciences, UCLA School of Dentistry, Los Angeles, CA, USA.
O BezouglaiaDivision of Diagnostic and Surgical Sciences, UCLA School of Dentistry, Los Angeles, CA, USA.
S M DryUCLA Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
F Q PirihDivision of Constitutive and Regenerative Sciences, UCLA School of Dentistry, Los Angeles, CA, USA.
T L AghalooDivision of Diagnostic and Surgical Sciences, UCLA School of Dentistry, Los Angeles, CA, USA.
S TetradisDivision of Diagnostic and Surgical Sciences, UCLA School of Dentistry, Los Angeles, CA, USA.
University of California, Los Angeles · US

Funding

UCLA FUNDAMENTAL CLINICAL RESEARCH TRAINING PROGRAMT32DE007296 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WONG, DAVID T · 1996 to 2011
$5.8M
Pathophysiologic Mechanisms of Bisphosphonate Related Osteonecrosis of the JawsR01DE019465 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TETRADIS, SOTIRIOS · 2009 to 2024
$5.4M
Defining the transcriptome in Osteonecrosis of the JawsF30DE028171 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HADAYA, DANNY ELIAS · 2018 to 2019
$78k
NIDCR NIH HHS F30 DE028171NIDCR NIH HHS R01 DE019465NIDCR NIH HHS T32 DE007296
6 · The paper itself

Abstract

Osteonecrosis of the jaws (ONJ), a severe side effect of antiresorptive medications, is characterized by exposed, nonhealing bone in the oral cavity. Treatment options for ONJ range from management of symptomology to surgical resection of the affected area. Antiresorptive discontinuation, often termed a "drug holiday," has been used for managing ONJ patients. Antiresorptives can be discontinued prior to oral surgical procedures, such as tooth extraction, to prevent ONJ development or in patients with established ONJ to accelerate healing. Here, our objective was to test these clinical scenarios using the potent bisphosphonate, zoledronic acid (ZA), and the denosumab surrogate for rodents, OPG-Fc, in a rat model of ONJ. Animals were pretreated with antiresorptives or saline, after which we induced ONJ using periapical disease and tooth extraction. In our first experimental design, antiresorptives were discontinued 1 wk prior to tooth extraction, and animals were evaluated 4 wk later for clinical, radiographic, and histologic features of ONJ. In the second experiment, ONJ was established and antiresorptives were discontinued for 4 wk. Discontinuation of OPG-Fc, but not ZA, prior to tooth extraction ameliorated subsequent ONJ development. In contrast, discontinuation of either ZA or OPG-Fc in rats with established ONJ did not lead to ONJ resolution. In conclusion, our findings suggest that antiresorptive discontinuation is dependent on both the type of antiresorptive and the timing of discontinuation.

Indexed as

Bisphosphonate-Associated Osteonecrosis of the JawBone Density Conservation AgentsPeriapical DiseasesAnimalsDiphosphonatesHumansRatsTooth ExtractionZoledronic AcidBone Density Conservation AgentsDiphosphonatesZoledronic Acidbone biologybone remodeling/regenerationoral and maxillofacial surgeryosteoclastsosteonecrosisosteoporosis

Identifiers

PMID33478337
PMCPMC8221704
OpenAlexW3122549856

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.