Evidence map›Paper›PMID 33478333›Full record

Observational studyRenal failure2021

A nomogram based on serum cystatin C for predicting acute kidney injury in patients with traumatic brain injury.

Ruo Ran Wang, Min He, Xiying Gui, Yan Kang

Registry-linked trialOpen access · goldAbstract readObservational Study
In one paragraph

Observational study in Renal failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06635408 (Cystatin c as a Predictive Biomarker of Acute Kidney Injury and Neurological Outcomes in Aneurysmal Subarachnoid Haemorrhage Patients), which is not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06635408 completednot on this mapstarted 2023, after this paper: background citation

Cystatin c as a Predictive Biomarker of Acute Kidney Injury and Neurological Outcomes in Aneurysmal Subarachnoid Haemorrhage Patients

TypeobservationalSponsorAlexandria UniversityRan2023 to 2025Enrolled52ConditionsAcute Kidney InjuryArmscystatin c
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  6. Observational
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  8. Association of hyperchloremia and acute kidney injury in pediatric patients with moderate and severe traumatic brain injury.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ruo Ran WangDepartment of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.
Min HeDepartment of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.
Xiying GuiDepartment of Critical Care Medicine, Tibet Autonomous Region People's Hospital, Lhasa, China.
Yan KangDepartment of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.ORCID https://orcid.org/0000-0002-5715-3900
Sichuan University · CNTibet Autonomous Region People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute kidney injury (AKI) is a common complication in traumatic brain injury (TBI) patients and is associated with unfavorable outcome of these patients. We designed this study to explore the value of serum cystatin C, an indicator of renal function, on predicting AKI after suffering TBI.

methodsPatients confirmed with TBI and hospitalized in the West China Hospital of Sichuan University between January 2015 and December 2019 were included. Patients were divided into two groups according to occurrence of AKI. Univariate and multivariate logistic regression analyses were sequentially utilized to find risk factors of AKI in included TBI patients. Nomogram composed of discovered risk factors for predicting AKI was constructed. Receiver operating characteristics (ROC) curves were drawn and area under the ROC curve (AUC) were calculated to evaluate the predictive value of cystatin C alone and the constructed nomogram.

resultsAmong 234 included TBI patients, 55 were divided into AKI group. AKI group had shorter length of stay (

conclusionHigher serum cystatin C is associated with development of AKI in TBI patients. Predictive nomogram incorporating cystatin C is beneficial for physicians to evaluate possibilities of AKI and consequently adjust treatment strategies to avoid occurrence of AKI.

Indexed as

Acute Kidney InjuryAdultBiomarkersBrain Injuries, TraumaticChinaCreatinineCystatin CFemaleHospital MortalityHumansLogistic ModelsMaleMiddle AgedNomogramsRetrospective StudiesRisk FactorsBiomarkersCreatinineCystatin Cacute kidney injurybiomarkerCystatin Ctraumatic brain injury

Identifiers

PMID33478333
PMCPMC7833079
OpenAlexW3125205410

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.