ArticlePathogens (Basel, Switzerland)2021
Accurate Diagnosis of Small Ruminant Lentivirus Infection Is Needed for Selection of Resistant Sheep through TMEM154 E35K Genotyping.
Article in Pathogens (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- Epidemiological Insights into Small Ruminant Lentiviruses in Portuguese Production Systems.Animals : an open access journal from MDPI · 2026Article
- Whole-genome resequencing of the Kazakh coarse-wool fat-tailed sheep identifies functional variants in disease-associated genes.Frontiers in veterinary science · 2026Article
- Permissiveness of different TMEM154 genotype cell lines to different SRLV genotypes/subtypes.Journal of virology · 2025Article
- Epidemiological landscape and genetic prospects for marker-assisted selection in Kazakh sheep.Frontiers in veterinary science · 2025Review
- Diagnostic Challenges and Patient Safety: The Critical Role of Accuracy - A Systematic Review.Journal of multidisciplinary healthcare · 2025Review
- Maedi-visna infection in Pomeranian Coarsewool Sheep in Germany: seroprevalence, environmental and genetic risk factors.Frontiers in veterinary science · 2025Article
- First Report of SNPs Detection in TMEM154 Gene in Sheep from Poland and Their Association with SRLV Infection Status.Pathogens (Basel, Switzerland) · 2024Article
- Molecular Characterization of Small Ruminant Lentiviruses in Sheep and Goats: A Systematic Review.Animals : an open access journal from MDPI · 2024Review
- Circulation of small ruminant lentivirus in endangered goat and sheep breeds of Southern Italy.Heliyon · 2024Article
- A high-density genome-wide approach reveals novel genetic markers linked to small ruminant lentivirus susceptibility in sheep.Frontiers in genetics · 2024Article
- The genetic variability of small-ruminant lentiviruses and its impact on tropism, the development of diagnostic tests and vaccines and the effectiveness of control programmes.Journal of veterinary research · 2023Article
- Article
- Alternative Molecular Tools for the Fight against Infectious Diseases of Small Ruminants: Native Sicilian Sheep Breeds and Maedi-Visna Genetic Susceptibility.Animals : an open access journal from MDPI · 2022Article
- Transcriptome Analysis for Genes Associated with Small Ruminant Lentiviruses Infection in Goats of Carpathian Breed.Viruses · 2021Article
- Serological, Molecular and Culture-Based Diagnosis of Lentiviral Infections in Small Ruminants.Viruses · 2021Review
- First Survey of SNPs inViruses · 2021Article
- A DNA Regulatory Element Haplotype at Zinc Finger Genes Is Associated with Host Resilience to Small Ruminant Lentivirus in Two Sheep Populations.Animals : an open access journal from MDPI · 2021Article
- Worldwide Prevalence of Small Ruminant Lentiviruses in Sheep: A Systematic Review and Meta-Analysis.Animals : an open access journal from MDPI · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Small ruminant lentiviruses (SRLV) cause an incurable multiorganic disease widely spread in sheep and goats that disturbs animal welfare and production. In the absence of a vaccine, control measures have been traditionally based on early diagnosis and breeding with virus-inactivated colostrum with segregation of seropositive animals. However, antigenic heterogeneity, poor antibody production due to low viral load, and single strain design of most available ELISA, pose a threat to SRLV diagnosis. Genome-wide association studies have described TMEM154 E35K polymorphism as a good genetic marker for selection of resistant animals in some American and European breeds. In this study, a multitargeted serological and virological screening of more than 500 animals from four different breeds (latxa, raza Navarra, assaf, and churra) attending to SRLV infection status was performed. Then, animals were genotyped to characterize TMEM154 E35K polymorphism. ELISA procedures, individually considered, only identified a proportion of the seropositive animals, and PCR detected a fraction of seronegative animals, globally offering different animal classifications according to SRLV infection status. TMEM154 allele frequency differed substantially among breeds and a positive association between seroprevalence and TMEM154 genotype was found only in one breed. Selection based on TMEM154 may be suitable for specific ovine breeds or SRLV strains, however generalization to the whole SRLV genetic spectrum, ovine breeds, or epidemiological situation may need further validation.
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