Evidence map›Paper›PMID 33477960›Full record

ArticleInternational journal of molecular sciences2021

An In Vivo Study of a Rat Fluid-Percussion-Induced Traumatic Brain Injury Model with [

Krishna Kanta Ghosh, Parasuraman Padmanabhan, Chang-Tong Yang, Zhimin Wang, Mathangi Palanivel, Kian Chye Ng, Jia Lu, Jan Carlstedt-Duke, Christer Halldin, Balázs Gulyás

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. GABABrain communications · 2026
    Article
  3. Standardizing the lateral fluid percussion model of trauma in marmosets (Callithrix jacchus): regional vulnerability and inflammatory response.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026
    Article
  4. Article
  5. Article
  6. Automated Synthesis of [Pharmaceuticals (Basel, Switzerland) · 2023
    Article
  7. Molecular Imaging in Nanomedical Research.International journal of molecular sciences · 2022
    Article
  8. Longitudinal [Biomedicines · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Krishna Kanta GhoshLee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921, Singapore.
Parasuraman PadmanabhanLee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921, Singapore.ORCID 0000-0003-4112-4600
Chang-Tong YangLee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921, Singapore.
Zhimin WangLee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921, Singapore.
Mathangi PalanivelLee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921, Singapore.ORCID 0000-0001-8710-4336
Kian Chye NgDSO National Laboratories (Kent Ridge), 27 Medical Drive, Singapore 117510, Singapore.
Jia LuDSO National Laboratories (Kent Ridge), 27 Medical Drive, Singapore 117510, Singapore.
Jan Carlstedt-DukePresident's Office, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore.ORCID 0000-0001-7784-5296
Christer HalldinLee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921, Singapore.
Balázs GulyásLee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921, Singapore.
Nanyang Technological University · SGDSO National Laboratories · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traumatic brain injury (TBI) modelled by lateral fluid percussion-induction (LFPI) in rats is a widely used experimental rodent model to explore and understand the underlying cellular and molecular alterations in the brain caused by TBI in humans. Current improvements in imaging with positron emission tomography (PET) have made it possible to map certain features of TBI-induced cellular and molecular changes equally in humans and animals. The PET imaging technique is an apt supplement to nanotheranostic-based treatment alternatives that are emerging to tackle TBI. The present study aims to investigate whether the two radioligands, [

Indexed as

AcetamidesAnimalsBrain Injuries, TraumaticCarbon RadioisotopesDisease Models, AnimalFlumazenilFluorine RadioisotopesMalePercussionPositron-Emission TomographyPyridinesRatsRats, Sprague-DawleyAcetamidesCarbon RadioisotopesFlumazenilFluorine-18Fluorine RadioisotopesN-(2-methoxybenzyl)-N-(4-phenoxypyridin-3-yl)acetamidePyridines[11C]PBR28[18F]flumazenilGABAA-benzodiazepine receptorlateral fluid percussion (LFP)neuroinflammationPET radioligandpositron emission tomography (PET)traumatic brain injury (TBI)

Identifiers

PMID33477960
PMCPMC7835883
OpenAlexW3121275255

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.