Evidence map›Paper›PMID 33477843›Full record

ArticlePharmaceutics2021

The Impact of Lipid Handling and Phase Distribution on the Acoustic Behavior of Microbubbles.

Simone A G Langeveld, Inés Beekers, Gonzalo Collado-Lara, Antonius F W van der Steen, Nico de Jong, Klazina Kooiman

Abstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Simone A G LangeveldThorax Center, Biomedical Engineering, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands.ORCID 0000-0001-7604-3013
Inés BeekersThorax Center, Biomedical Engineering, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands.ORCID 0000-0003-0905-5422
Gonzalo Collado-LaraThorax Center, Biomedical Engineering, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands.ORCID 0000-0002-1010-6242
Antonius F W van der SteenThorax Center, Biomedical Engineering, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands.
Nico de JongThorax Center, Biomedical Engineering, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands.ORCID 0000-0001-8902-0099
Klazina KooimanThorax Center, Biomedical Engineering, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands.

Funding

Phospholipid Research Center KKO-2017-057/1-1Thorax Center, Erasmus MC xxx
6 · The paper itself

Abstract

Phospholipid-coated microbubbles are ultrasound contrast agents that can be employed for ultrasound molecular imaging and drug delivery. For safe and effective implementation, microbubbles must respond uniformly and predictably to ultrasound. Therefore, we investigated how lipid handling and phase distribution affected the variability in the acoustic behavior of microbubbles. Cholesterol was used to modify the lateral molecular packing of 1,2-distearoyl-

Indexed as

acoustic responsecholesterolligand distributionlipid phasemicrobubblephospholipid coatingultrasound contrast agents

Identifiers

PMID33477843
PMCPMC7832861

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.