ArticleNutrients2021
Higher Intakes of Potassium and Magnesium, but Not Lower Sodium, Reduce Cardiovascular Risk in the Framingham Offspring Study.
Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 45 citations in OpenAlex.
- A Retrospective Study: Do Hospital Menus Carry a Risk of Malnutrition?Food science & nutrition · 2025Article
- Inquiry of the Metabolic Traits in Relationship with Daily Magnesium Intake: Focus on Type 2 Diabetic Population.Clinics and practice · 2024Review
- Dietary Calcium and Vascular Calcification: The Way to One's Heart Isn't Always Through the Stomach.JACC. Advances · 2024Article
- Potassium - a scoping review for Nordic Nutrition Recommendations 2023.Food & nutrition research · 2024Article
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- Article
- The Effect of a Vegan Diet on the Cardiovascular System.Journal of cardiovascular development and disease · 2023Review
- Vegan diet: nutritional components, implementation, and effects on adults' health.Frontiers in nutrition · 2023Review
- Article
- Differentiating Wild and Apiary Honey by Elemental Profiling: a Case Study from Mangroves of Indian Sundarban.Biological trace element research · 2022Article
- Article
- Potato consumption is not associated with cardiometabolic health outcomes in Framingham Offspring Study adults.Journal of nutritional science · 2022Article
- Cross-Talks between the Cardiovascular Disease-Sarcopenia-Osteoporosis Triad and Magnesium in Humans.International journal of molecular sciences · 2021Review
- Global Variations in the Mineral Content of Bottled Still and Sparkling Water and a Description of the Possible Impact on Nephrological and Urological Diseases.Journal of clinical medicine · 2021Article
- Dietary Intake and Chronic Disease Prevention.Nutrients · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We explored the dose-response relations of sodium, potassium, magnesium and calcium with cardiovascular disease (CVD) risk in the Framingham Offspring Study, as well as the combined effects of these minerals. Analyses included 2362 30-64 year-old men and women free of CVD at baseline. Cox proportional-hazards models were used estimate adjusted hazard ratios (HR) and 95% confidence intervals (CIs) for mineral intakes and incident CVD. Cox models with restricted cubic spline functions were used to examine dose-response relations, adjusting for confounding by age, sex, body mass index, dietary fiber intake, and time-varying occurrence of hypertension. Lower sodium intake (<2500 vs. ≥3500 mg/d) was not associated with a lower risk of CVD. In contrast, potassium intake ≥3000 (vs. <2500) mg/d was associated with a 25% lower risk (95% CI: 0.59, 0.95), while magnesium intake ≥320 (vs. <240) mg/d led to a 34% lower risk (95% CI: 0.51, 0.87) of CVD. Calcium intake ≥700 (vs. <500) mg/d was associated with a non-statistically significant 19% lower risk. Restricted cubic spline curves showed inverse dose-response relations of potassium and magnesium with CVD risk, but no such associations were observed for sodium or calcium. These results highlight the importance of potassium and magnesium to cardiovascular health.
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Registered trials
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