Evidence map›Paper›PMID 33477751›Full record

ArticleCancers2021

The Giant HECT E3 Ubiquitin Ligase HERC1 Is Aberrantly Expressed in Myeloid Related Disorders and It Is a Novel BCR-ABL1 Binding Partner.

Muhammad Shahzad Ali, Cristina Panuzzo, Chiara Calabrese, Alessandro Maglione, Rocco Piazza, Daniela Cilloni, Giuseppe Saglio, Barbara Pergolizzi, Enrico Bracco

Abstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. The Downregulation of Both Giant HERCs,Journal of clinical medicine · 2022
    Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Muhammad Shahzad AliDepartment of Clinical and Biological Science, Medical School, University of Torino, 10043 Orbassano, Italy.ORCID 0000-0001-6234-8369
Cristina PanuzzoDepartment of Clinical and Biological Science, Medical School, University of Torino, 10043 Orbassano, Italy.
Chiara CalabreseDepartment of Clinical and Biological Science, Medical School, University of Torino, 10043 Orbassano, Italy.
Alessandro MaglioneDepartment of Clinical and Biological Science, Medical School, University of Torino, 10043 Orbassano, Italy.ORCID 0000-0001-7153-2248
Rocco PiazzaDepartment of Health Sciences, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0003-4198-9620
Daniela CilloniDepartment of Clinical and Biological Science, Medical School, University of Torino, 10043 Orbassano, Italy.ORCID 0000-0001-6346-4791
Giuseppe SaglioDepartment of Clinical and Biological Science, Medical School, University of Torino, 10043 Orbassano, Italy.
Barbara PergolizziDepartment of Clinical and Biological Science, Medical School, University of Torino, 10043 Orbassano, Italy.ORCID 0000-0003-4686-0068
Enrico BraccoDepartment of Oncology, Medical School, University of Torino, 10043 Orbassano, Italy.ORCID 0000-0003-3170-2817

Funding

Associazione Italiana per la Ricerca sul Cancro 10005Research funding from the Università degli Studi di Torino PERB_RILO_18_01
6 · The paper itself

Abstract

HERC E3 subfamily members are parts of the E3 ubiquitin ligases and key players for a wide range of cellular functions. Though the involvement of the Ubiquitin Proteasome System in blood disorders has been broadly studied, so far the role of large HERCs in this context remains unexplored. In the present study we examined the expression of the large HECT E3 Ubiquitin Ligase, HERC1, in blood disorders. Our findings revealed that

Indexed as

Bcr-Abl1E3 ubiquitin ligasesgene expressionHERC1myeloid neoplasmsprotein–protein interactionubiquitin proteasome system

Identifiers

PMID33477751
PMCPMC7832311

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.