ArticleCancers2021
Radiomics and Dosiomics for Predicting Local Control after Carbon-Ion Radiotherapy in Skull-Base Chordoma.
Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07702838 (A Prospective Clinical Study of Immunotherapy Combined With Carbon Ion Radiotherapy for Locally Advanced Cervical Cancer), which is not on this map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective Clinical Study of Immunotherapy Combined With Carbon Ion Radiotherapy for Locally Advanced Cervical Cancer
Who cites it
27 citing papers in PubMed, 54 citations in OpenAlex.
- Article
- Machine learning in automatic detection of chordoma signature, postoperative residuals, and prognosis of skull base chordomas.NPJ precision oncology · 2026Article
- Multi-omics predicts radiotherapy response in small cell lung cancer patients receiving whole brain irradiation.Journal of applied clinical medical physics · 2026Article
- Machine learning-based integration of dosiomics and pre-radiotherapy multimodal MRI radiomics for survival stratification in patients with glioblastoma multiforme.Radiation oncology (London, England) · 2025Article
- Radiomic Applications in Skull Base Pathology: A Systematic Review of Potential Clinical Uses.Journal of neurological surgery. Part B, Skull base · 2025Article
- Development and validation of a prediction model based on two-dimensional dose distribution maps fused with computed tomography images for noninvasive prediction of radiochemotherapy resistance in non-small cell lung cancer.Translational cancer research · 2025Article
- Radiogenomic method combining DNA methylation profiles and magnetic resonance imaging radiomics predicts patient prognosis in skull base chordoma.Clinical epigenetics · 2025Article
- Particle Beam Radiobiology Status and Challenges: A PTCOG Radiobiology Subcommittee Report.International journal of particle therapy · 2024Review
- Radiomic- and dosiomic-based clustering development for radio-induced neurotoxicity in pediatric medulloblastoma.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Article
- CT and MRI radiomics of bone and soft-tissue sarcomas: an updated systematic review of reproducibility and validation strategies.Insights into imaging · 2024Article
- A novel CT-based radiomics model for predicting response and prognosis of chemoradiotherapy in esophageal squamous cell carcinoma.Scientific reports · 2024Article
- Dosiomics for intensity-modulated radiotherapy in patients with prostate cancer: survival analysis stratified by baseline prostate-specific antigen and Gleason grade group in a 2-institutional retrospective study.The British journal of radiology · 2024Article
- Review
- Applications and Integration of Radiomics for Skull Base Oncology.Advances in experimental medicine and biology · 2024Review
- Radiomics and dosiomics for predicting radiation-induced hypothyroidism and guiding intensity-modulated radiotherapy.iScience · 2023Article
- Frontiers of Cranial Base Surgery: Integrating Technique, Technology, and Teamwork for the Future of Neurosurgery.Brain sciences · 2023Review
- Radiation pneumonia predictive model for radiotherapy in esophageal carcinoma patients.BMC cancer · 2023Article
- Application of error classification model using indices based on dose distribution for characteristics evaluation of multileaf collimator position errors.Scientific reports · 2023Article
- Stability of dosiomic features against variations in dose calculation: An analysis based on a cohort of prostate external beam radiotherapy patients.Journal of applied clinical medical physics · 2023Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skull-base chordoma (SBC) can be treated with carbon ion radiotherapy (CIRT) to improve local control (LC). The study aimed to explore the role of multi-parametric radiomic, dosiomic and clinical features as prognostic factors for LC in SBC patients undergoing CIRT. Before CIRT, 57 patients underwent MR and CT imaging, from which tumour contours and dose maps were obtained. MRI and CT-based radiomic, and dosiomic features were selected and fed to two survival models, singularly or by combining them with clinical factors. Adverse LC was given by in-field recurrence or tumour progression. The dataset was split in development and test sets and the models' performance evaluated using the concordance index (C-index). Patients were then assigned a low- or high-risk score. Survival curves were estimated, and risk groups compared through log-rank tests (after Bonferroni correction α = 0.0083). The best performing models were built on features describing tumour shape and dosiomic heterogeneity (median/interquartile range validation C-index: 0.80/024 and 0.79/0.26), followed by combined (0.73/0.30 and 0.75/0.27) and CT-based models (0.77/0.24 and 0.64/0.28). Dosiomic and combined models could consistently stratify patients in two significantly different groups. Dosiomic and multi-parametric radiomic features showed to be promising prognostic factors for LC in SBC treated with CIRT.
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