ArticleVeterinary sciences2021
Differentiation of Antibodies against Selected Simbu Serogroup Viruses by a Glycoprotein Gc-Based Triplex ELISA.
Article in Veterinary sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 28 citations in OpenAlex.
- Epidemiological investigation of Shuni virus infections in hospitals in two provinces of South Africa (2019-2021) using molecular and serological surveillance.PLoS neglected tropical diseases · 2026Article
- Climatic Associations of Akabane Virus Occurrence in East Asia: Temperature-Driven Patterns Based on the Köppen-Geiger Classification.Microorganisms · 2026Article
- Review
- Mysterious Oropouche virus: Transmission, symptoms, and control.Infectious medicine · 2025Review
- Factors influencing Akabane virus seroprevalence in sheep and goats in Egypt's Nile Delta.Tropical animal health and production · 2025Article
- Research progress on the N gene of Akabane virus.Frontiers in veterinary science · 2025Review
- Phylogenetic analysis and biological characteristics of an Akabane virus isolated in China.Frontiers in veterinary science · 2025Article
- The Adaptive Immune Response againstViruses · 2024Review
- Article
- First evidence of schmallenberg virus infection in southern Italy.BMC veterinary research · 2023Article
- Serological screening in wild ruminants in Germany, 2021/2022: No evidence of SARS-CoV-2, bluetongue virus or pestivirus spread but high seroprevalences against Schmallenberg virus.Transboundary and emerging diseases · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The Simbu serogroup of orthobunyaviruses includes several pathogens of veterinary importance, among them Schmallenberg virus (SBV), Akabane virus (AKAV) and Shuni virus (SHUV). They infect predominantly ruminants and induce severe congenital malformation. In adult animals, the intra vitam diagnostics by direct virus detection is limited to only a few days due to a short-lived viremia. For surveillance purposes the testing for specific antibodies is a superior approach. However, the serological differentiation is hampered by a considerable extent of cross-reactivity, as viruses were assigned into this serogroup based on antigenic relatedness. Here, we established a glycoprotein Gc-based triplex enzyme-linked immunosorbent assay (ELISA) for the detection and differentiation of antibodies against SBV, AKAV, and SHUV. A total of 477 negative samples of various ruminant species, 238 samples positive for SBV-antibodies, 36 positive for AKAV-antibodies and 53 SHUV antibody-positive samples were tested in comparison to neutralization tests. For the newly developed ELISA, overall diagnostic specificities of 84.56%, 94.68% and 89.39% and sensitivities of 89.08%, 69.44% and 84.91% were calculated for SBV, AKAV and SHUV, respectively, with only slight effects of serological cross-reactivity on the diagnostic specificity. Thus, this test system could be used for serological screening in suspected populations or as additional tool during outbreak investigations.
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