Evidence map›Paper›PMID 33477716›Full record

ArticleBiomolecules2021

Molecular Basis of NDT-Mediated Activation of Nucleoside-Based Prodrugs and Application in Suicide Gene Therapy.

Javier Acosta, Elena Pérez, Pedro A Sánchez-Murcia, Cristina Fillat, Jesús Fernández-Lucas

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Magnetic Multi-Enzymatic System for Cladribine Manufacturing.International journal of molecular sciences · 2022
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Javier AcostaApplied Biotechnology Group, European University of Madrid, c/ Tajo s/n, Villaviciosa de Odón, 28670 Madrid, Spain.ORCID 0000-0002-7066-2523
Elena PérezApplied Biotechnology Group, European University of Madrid, c/ Tajo s/n, Villaviciosa de Odón, 28670 Madrid, Spain.
Pedro A Sánchez-MurciaDivision of Physiological Chemistry, Otto-Loewi Research Center, Medical University of Graz, Neue Stiftingtalstraße 6/III, A-8010 Graz, Austria.
Cristina FillatInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
Jesús Fernández-LucasDivision of Physiological Chemistry, Otto-Loewi Research Center, Medical University of Graz, Neue Stiftingtalstraße 6/III, A-8010 Graz, Austria.ORCID 0000-0001-7045-8306
Medical University of Graz · ATUniversidad Europea de Madrid · ESCentre for Biomedical Network Research on Rare Diseases · ES

Funding

Fundación Banco Santander XSAN192006Generalitat de Catalunya SGR17/861Spanish Ministry of Economia y Competitividad BIO2017-89754-C2-Universidad Europea de Madrid 2020/UEM42
6 · The paper itself

Abstract

Herein we report the first proof for the application of type II 2'-deoxyribosyltransferase from

Indexed as

Genes, Transgenic, SuicideDeoxyadenosinesFluorouracilGlycoside HydrolasesGlycosylationHeLa CellsHumansLactobacillusMolecular Dynamics SimulationNucleosidesPentosyltransferasesProdrugs2'-deoxy-2-fluoroadenosine2'-fluoro-2'-deoxyadenosineDeoxyadenosinesFluorouracilGlycoside Hydrolasesnucleoside deoxyribosyltransferaseNucleosidesPentosyltransferasesProdrugs2′-deoxyribosyltransferasechemotherapymolecular dynamicsnucleoside analoguesstructural bioinformaticssuicide gene therapy

Identifiers

PMID33477716
PMCPMC7831932
OpenAlexW3123020067

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.