Evidence map›Paper›PMID 33477692›Full record

ArticleInternational journal of molecular sciences2021

CD73

Nabila Seddiki, John Zaunders, Chan Phetsouphanh, Vedran Brezar, Yin Xu, Helen M McGuire, Michelle Bailey, Kristin McBride, Will Hey-Cunningham, Cynthia Mee Ling Munier and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. CD73 Expression by CD4Immunology · 2025
    Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 2 countries.

Nabila SeddikiINSERM U955, Equipe 16, 94000 Créteil, France.
John ZaundersCentre for Applied Medical Research, St Vincent's Hospital, Sydney, NSW 2010, Australia.
Chan PhetsouphanhKirby Institute, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0001-6617-5995
Vedran BrezarINSERM U955, Equipe 16, 94000 Créteil, France.
Yin XuKirby Institute, University of New South Wales, Sydney, NSW 2052, Australia.
Helen M McGuireCharles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia.ORCID 0000-0003-2047-6543
Michelle BaileyKirby Institute, University of New South Wales, Sydney, NSW 2052, Australia.
Kristin McBrideKirby Institute, University of New South Wales, Sydney, NSW 2052, Australia.
Will Hey-CunninghamKirby Institute, University of New South Wales, Sydney, NSW 2052, Australia.
Cynthia Mee Ling MunierKirby Institute, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0002-6419-142X
Laura CookKirby Institute, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0003-3153-2045
Stephen KentDepartment of Microbiology and Immunology, University of Melbourne, Melbourne, VIC 3010, Australia.
Andrew LloydKirby Institute, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0001-6277-8887
Barbara CameronSchool of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
Barbara Fazekas de St GrothCharles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia.
Kersten KoelschKirby Institute, University of New South Wales, Sydney, NSW 2052, Australia.
Mark DantaSt Vincent's Clinical School, St Vincent's Hospital and University of New South Wales, Sydney, NSW 2052, Australia.
Hakim HociniINSERM U955, Equipe 16, 94000 Créteil, France.
Yves LevyINSERM U955, Equipe 16, 94000 Créteil, France.
Anthony D KelleherKirby Institute, University of New South Wales, Sydney, NSW 2052, Australia.
UNSW Sydney · AUInserm · FRThe University of Sydney · AUThe University of Melbourne · AU

Funding

National Health and Medical Research Council 1037298National Health and Medical Research Council 1052979National Health and Medical Research Council 1063422
6 · The paper itself

Abstract

HIV-1 infection rapidly leads to a loss of the proliferative response of memory CD4+ T lymphocytes, when cultured with recall antigens. We report here that CD73 expression defines a subset of resting memory CD4+ T cells in peripheral blood, which highly express the α-chain of the IL-7 receptor (CD127), but not CD38 or Ki-67, yet are highly proliferative in response to mitogen and recall antigens, and to IL-7, in vitro. These cells also preferentially express CCR5 and produce IL-2. We reasoned that CD73+ memory CD4+ T cells decrease very early in HIV-1 infection. Indeed, CD73+ memory CD4+ T cells comprised a median of 7.5% (interquartile range: 4.5-10.4%) of CD4+ T cells in peripheral blood from healthy adults, but were decreased in primary HIV-1 infection to a median of 3.7% (IQR: 2.6-6.4%;

Indexed as

Molecular Targeted Therapy5'-NucleotidaseAntigens, CDCell LineageCell ProliferationHIV-1HIV InfectionsHumansInterleukin-7 Receptor alpha SubunitMemory, Long-Term5'-NucleotidaseAntigens, CDInterleukin-7 Receptor alpha SubunitCD4+ subsetsCD73HIV-1 viral reservoir

Identifiers

PMID33477692
PMCPMC7831934
OpenAlexW3121668273

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.