Evidence map›Paper›PMID 33477579›Full record

ArticleJournal of clinical medicine2021

Association of NAFLD and Insulin Resistance with Non Metastatic Bladder Cancer Patients: A Cross-Sectional Retrospective Study.

Giovanni Tarantino, Felice Crocetto, Concetta Di Vito, Massimiliano Creta, Raffaele Martino, Savio Domenico Pandolfo, Salvatore Pesce, Luigi Napolitano, Domenico Capone, Ciro Imbimbo

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 2 pooled it
17.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 2 syntheses or guidelines pooled it, 129 citations in OpenAlex.

  1. Pooled it
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  16. Advances in the Use of Metformin for Liver Disease.Current medicinal chemistry · 2025
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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Giovanni TarantinoDepartment of Clinical Medicine and Surgery, Federico II Medical School, Via S. Pansini 5, 80131 Naples, Italy.ORCID 0000-0001-7751-2715
Felice CrocettoDepartment of Neuroscience, Reproductive Sciences and Dentistry, University of Naples "Federico II", Via S. Pansini 5, 80131 Naples, Italy.
Concetta Di VitoDepartment of Neuroscience, Reproductive Sciences and Dentistry, University of Naples "Federico II", Via S. Pansini 5, 80131 Naples, Italy.
Massimiliano CretaDepartment of Neuroscience, Reproductive Sciences and Dentistry, University of Naples "Federico II", Via S. Pansini 5, 80131 Naples, Italy.
Raffaele MartinoDepartment of Neuroscience, Reproductive Sciences and Dentistry, University of Naples "Federico II", Via S. Pansini 5, 80131 Naples, Italy.
Savio Domenico PandolfoDepartment of Neuroscience, Reproductive Sciences and Dentistry, University of Naples "Federico II", Via S. Pansini 5, 80131 Naples, Italy.
Salvatore PesceDepartment of Neuroscience, Reproductive Sciences and Dentistry, University of Naples "Federico II", Via S. Pansini 5, 80131 Naples, Italy.
Luigi NapolitanoDepartment of Neuroscience, Reproductive Sciences and Dentistry, University of Naples "Federico II", Via S. Pansini 5, 80131 Naples, Italy.
Domenico CaponeClinical Pharmacology Consultant, Via Volturno 27, 80026 Naples, Italy.
Ciro ImbimboDepartment of Neuroscience, Reproductive Sciences and Dentistry, University of Naples "Federico II", Via S. Pansini 5, 80131 Naples, Italy.
University of Naples Federico II · ITFederico II University Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Among risk factors (apart from smoking) likely involved in bladder cancer (BCa), metabolic syndrome (MS), obesity and type 2 diabetes mellitus (T2DM) have been explored with contrasting results. In spite of these studies, there is little data on the association between nonalcoholic fatty liver disease (NAFLD), its main driver, i.e., insulin resistance (IR), and BCa. Implanting a cross-sectional retrospective study we tried to investigate both NAFLD and IR prevalence in a hospital based population of BCa patients. We studied laboratory data from 204 patients with histologically confirmed non metastatic BCa and 50 subjects with no BCa, but with bladder diseases (no Ca BD). We evaluated the presence of NAFLD by the triglycerides/glucose Index (TyG Index), using a cut-off of 0.59 and by the Aspartate Aminotransferase/Alanine Aminotransferase AST/ALT ratio. IR was assessed by the same TyG Index (cut-off 4.68) and the triglycerides/High-Density Lipoprotein HDL ratio (cut-off 2.197). The diagnosis of impaired fasting glucose (IFG), condition of prediabetes, as well as that of T2DM was assessed according to canonical guidelines. The TyG Index predicted NAFLD presence in both groups (

Indexed as

bladder cancerimpaired fasting glucoseinsulin resistanceNAFLDno cancerous bladder diseasesprediabetestype 2 diabetes mellitus

Identifiers

PMID33477579
PMCPMC7831331
OpenAlexW3121434091

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.