Evidence map›Paper›PMID 33477525›Full record

ArticleInternational journal of molecular sciences2021

Overexpression of Adiponectin Receptor 1 Inhibits Brown and Beige Adipose Tissue Activity in Mice.

Yu-Jen Chen, Chiao-Wei Lin, Yu-Ju Peng, Chao-Wei Huang, Yi-Shan Chien, Tzu-Hsuan Huang, Pei-Xin Liao, Wen-Yuan Yang, Mei-Hui Wang, Harry J Mersmann and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Yu-Jen ChenInstitute of Biotechnology, National Taiwan University, Taipei 10617, Taiwan.
Chiao-Wei LinInstitute of Biotechnology, National Taiwan University, Taipei 10617, Taiwan.
Yu-Ju PengDepartment of Animal Science and Technology, National Taiwan University, Taipei 10617, Taiwan.
Chao-Wei HuangDepartment of Animal Science and Technology, National Taiwan University, Taipei 10617, Taiwan.ORCID 0000-0002-2760-7721
Yi-Shan ChienDepartment of Animal Science and Technology, National Taiwan University, Taipei 10617, Taiwan.
Tzu-Hsuan HuangDepartment of Animal Science and Technology, National Taiwan University, Taipei 10617, Taiwan.
Pei-Xin LiaoDepartment of Animal Science and Technology, National Taiwan University, Taipei 10617, Taiwan.
Wen-Yuan YangDepartment of Animal Science and Technology, National Taiwan University, Taipei 10617, Taiwan.
Mei-Hui WangInstitute of Nuclear Energy Research, Taoyuan 325, Taiwan.
Harry J MersmannDepartment of Animal Science and Technology, National Taiwan University, Taipei 10617, Taiwan.
Shinn-Chih WuInstitute of Biotechnology, National Taiwan University, Taipei 10617, Taiwan.
Tai-Yuan ChuangDepartment of Athletics, National Taiwan University, Taipei 10617, Taiwan.
Yuan-Yu LinDepartment of Animal Science and Technology, National Taiwan University, Taipei 10617, Taiwan.ORCID 0000-0002-3397-3218
Wen-Hung KuoDepartment of Surgery, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei 10617, Taiwan.
Shih-Torng DingInstitute of Biotechnology, National Taiwan University, Taipei 10617, Taiwan.
National Taiwan University of Science and Technology · TWInstitute of Nuclear Energy Research · TWNational Taiwan University · TWNational Taiwan University Hospital · TW

Funding

CSRD VA 1
6 · The paper itself

Abstract

Adult humans and mice possess significant classical brown adipose tissues (BAT) and, upon cold-induction, acquire brown-like adipocytes in certain depots of white adipose tissues (WAT), known as beige adipose tissues or WAT browning/beiging. Activating thermogenic classical BAT or WAT beiging to generate heat limits diet-induced obesity or type-2 diabetes in mice. Adiponectin is a beneficial adipokine resisting diabetes, and causing "healthy obese" by increasing WAT expansion to limit lipotoxicity in other metabolic tissues during high-fat feeding. However, the role of its receptors, especially adiponectin receptor 1 (AdipoR1), on cold-induced thermogenesis in vivo in BAT and in WAT beiging is still elusive. Here, we established a cold-induction procedure in transgenic mice over-expressing AdipoR1 and applied a live 3-D [

Indexed as

Adipocytes, BeigeAdipose Tissue, BeigeAdipose Tissue, BrownAdipose Tissue, WhiteAnimalsEnergy MetabolismGene Expression Regulation, DevelopmentalMiceMice, TransgenicMitochondriaObesityPositron-Emission TomographyReceptors, AdiponectinThermogenesisUncoupling Protein 1adiponectin receptor 1, mouseReceptors, AdiponectinUcp1 protein, mouseUncoupling Protein 1adiponectinadiponectin receptor 1beige adipose tissuebrown adipose tissuecold-induced thermogenesisPET/CT scintigraphyuncoupling protein 1 (UCP1)

Identifiers

PMID33477525
PMCPMC7831094
OpenAlexW3123686690

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.