Evidence map›Paper›PMID 33477436›Full record

ArticleAntibiotics (Basel, Switzerland)2021

Grapefruit Seed Extract as a Natural Derived Antibacterial Substance against Multidrug-Resistant Bacteria.

Hee-Won Han, Jin-Hwan Kwak, Tae-Su Jang, Jonathan Campbell Knowles, Hae-Won Kim, Hae-Hyoung Lee, Jung-Hwan Lee

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Activity of BiocidinFrontiers in antibiotics · 2025
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  10. Review
  11. Article
  12. International journal of molecular sciences · 2021
    Review
  13. Article
  14. Article
  15. Article
  16. Polyphenol-RichAntibiotics (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Hee-Won HanInstitute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, Chungcheongnam-do 31116, Korea.
Jin-Hwan KwakDepartment of Life Science, Handong Global University, 558 Handong-ro, Pohang, Gyeongsangbuk-do 37554, Korea.ORCID 0000-0003-3613-5380
Tae-Su JangDepartment of Pre-Medi, College of Medicine, Dankook University, 119 Dandae-ro, Cheonan, Chungcheongnam-do 31116, Korea.
Jonathan Campbell KnowlesInstitute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, Chungcheongnam-do 31116, Korea.ORCID 0000-0003-3917-3446
Hae-Won KimInstitute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, Chungcheongnam-do 31116, Korea.
Hae-Hyoung LeeInstitute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, Chungcheongnam-do 31116, Korea.
Jung-Hwan LeeInstitute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, Chungcheongnam-do 31116, Korea.ORCID 0000-0001-8678-5459
Dankook University · KRHandong Global University · KRUniversity College London · GB

Funding

Global Research Development Center 2018K1A4A3A01064257Ministry of Science and ICT, South Korea 2020R1A2C1005867National Research Foundation of Korea 2019R1C1C1002490Priority Research Center 2019R1A6A1A11034536
6 · The paper itself

Abstract

Multidrug-resistant (MDR) bacteria are increasing due to the abuse and misuse of antibiotics, and nosocomial infections by MDR bacteria are also increasing. The aim of this study was to identify new substances that can target MDR bacteria among 12 plant extracts that are known to have antibacterial effects. The experiments were performed by the disk diffusion test and microdilution minimum inhibitory concentration (MIC) test, as described by the Clinical and Laboratory Standards Institute (CLSI). By screening against methicillin-sensitive

Indexed as

antibacterial activitygrapefruit seed extractmultidrug-resistant bacterianosocomial infectionplant extract

Identifiers

PMID33477436
PMCPMC7830962
OpenAlexW3125523880

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.