Evidence map›Paper›PMID 33477417›Full record

ReviewJournal of clinical medicine2021

Gut Microbiota Modulation and Fecal Transplantation: An Overview on Innovative Strategies for Hepatic Encephalopathy Treatment.

Ramzi Hassouneh, Jasmohan S Bajaj

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Microbial Approaches to Treat and Prevent Hepatic Encephalopathy.Gastroenterology clinics of North America · 2025
    Review
  7. Article
  8. Review
  9. Article
  10. Observational
  11. Review
  12. Antibiotics (Basel, Switzerland) · 2024
    Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Ramzi HassounehDepartment of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA.
Jasmohan S BajajDivision of Gastroenterology, Hepatology and Nutrition Virginia Commonwealth University and Central Virginia Veterans Healthcare System, 1201 Broad Rock Blvd, Richmond, VA 23249, USA.
Virginia Commonwealth University · USVirginia Commonwealth University Medical Center · US

Funding

Gut Microbiota in the Modulation of Outcomes after Liver TransplantR21TR003095 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI BAJAJ, JASMOHAN S, VERNA, ELIZABETH CLARICE · 2020 to 2021
$448k
Modulation of Gut-Brain Axis Using Fecal Microbiome Transplant Capsules in CirrhosisR21TR002024 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI BAJAJ, JASMOHAN S · 2017 to 2018
$414k
NCATS NIH HHS R21TR002024NCATS NIH HHS R21TR003095Office of Research and Development 2I0CX001076
6 · The paper itself

Abstract

Hepatic encephalopathy (HE) is a major complication of cirrhosis, which is associated with gut microbial composition and functional alterations. Current treatments largely focus on gut microbiota using lactulose, rifaximin and other agents. However, despite these treatments, patients with HE have a high rate of readmission, morbidity and cognitive impairment. Fecal microbiota transplant (FMT) involves introduction of a donor microbiota into a recipient and is currently mainly used for recurrent

Indexed as

antibiotic resistancebile acidscapsulescirrhosiscognitive functionenemahospitalizations

Identifiers

PMID33477417
PMCPMC7830387
OpenAlexW3126054399

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.