Evidence map›Paper›PMID 33477414›Full record

ArticleInternational journal of molecular sciences2021

Directed Evolution of the

David G Schwark, Margaret A Schmitt, John D Fisk

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Biosynthesis, Engineering, and Delivery of Selenoproteins.International journal of molecular sciences · 2023
    Review
  7. Article
  8. Genetic Code Expansion: Another Solution to Codon Assignments.International journal of molecular sciences · 2022
    Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

David G SchwarkDepartment of Chemistry, University of Colorado Denver, Campus Box 194, P.O. Box 173364, Denver, CO 80217-3364, USA.
Margaret A SchmittDepartment of Chemistry, University of Colorado Denver, Campus Box 194, P.O. Box 173364, Denver, CO 80217-3364, USA.
John D FiskDepartment of Chemistry, University of Colorado Denver, Campus Box 194, P.O. Box 173364, Denver, CO 80217-3364, USA.ORCID 0000-0001-9809-6140
University of Colorado Denver · US

Funding

National Science Foundation CHE-1507055
6 · The paper itself

Abstract

Genetic code expansion has largely focused on the reassignment of amber stop codons to insert single copies of non-canonical amino acids (ncAAs) into proteins. Increasing effort has been directed at employing the set of aminoacyl tRNA synthetase (aaRS) variants previously evolved for amber suppression to incorporate multiple copies of ncAAs in response to

Indexed as

Directed Molecular EvolutionAmino AcidsAmino Acyl-tRNA SynthetasesCodonCodon, TerminatorEscherichia coliGenetic CodeMethanosarcina barkeriProtein BiosynthesisRNA, TransferTyrosineAmino AcidsAmino Acyl-tRNA SynthetasesCodonCodon, TerminatorRNA, TransferTyrosinedirected evolutiongenetic code expansionprotein engineeringpyrrolysyl tRNApyrrolysyl tRNA synthetasesense codon reassignmentsynthetic biology

Identifiers

PMID33477414
PMCPMC7830368
OpenAlexW3122766064

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.