Evidence map›Paper›PMID 33477363›Full record

ArticleVaccines2021

Plant-Produced Antigen Displaying Virus-Like Particles Evokes Potent Antibody Responses against West Nile Virus in Mice.

Junyun He, Huafang Lai, Adrian Esqueda, Qiang Chen

Abstract read
In one paragraph

Article in Vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Development of Antibody-Based Therapeutics Against West Nile Virus in Plants.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  11. Plant-Derived Human Vaccines: Recent Developments.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2022
    Review
  12. Virus-like Particles: Fundamentals and Biomedical Applications.International journal of molecular sciences · 2022
    Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Junyun HeThe Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.
Huafang LaiThe Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.
Adrian EsquedaThe Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.
Qiang ChenThe Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.ORCID 0000-0003-1498-7013

Funding

Plant-derived MAb therapeutics for west nile virusU01AI075549 · NIAID · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI CHEN, QIANG · 2007 to 2010
$1.6M
Bifunctional antibodies with targeted CNS delivery against West Nile virusR21AI101329 · NIAID · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI CHEN, QIANG · 2012 to 2013
$428k
NIAID NIH HHS R21 AI101329NIAID NIH HHS U01 AI075549NIH HHS U01 AI075549 and R21 AI101329
6 · The paper itself

Abstract

In this study, we developed a hepatitis B core antigen (HBcAg)-based virus-like particle (VLP) that displays the West Nile virus (WNV) Envelope protein domain III (wDIII) as a vaccine candidate for WNV. The HBcAg-wDIII fusion protein was quickly produced in

Indexed as

domain III (DIII)envelope proteinplant-made vaccinevaccinevirus-like particle (VLP)West Nile virus

Identifiers

PMID33477363
PMCPMC7830312

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.