Evidence map›Paper›PMID 33477359›Full record

ArticleSensors (Basel, Switzerland)2021

Using Wearable Sensor Technology to Measure Motion Complexity in Infants at High Familial Risk for Autism Spectrum Disorder.

Rujuta B Wilson, Sitaram Vangala, David Elashoff, Tabitha Safari, Beth A Smith

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07504224 (Feasibility of Wearable Devices as a Source of Data to Support HealthAI in Autism Spectrum Disorder Populations), which is not on this map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07504224 nacompletednot on this mapstarted 2024, after this paper: background citation

Feasibility of Wearable Devices as a Source of Data to Support HealthAI in Autism Spectrum Disorder Populations

TypeinterventionalSponsorRady Pediatric Genomics & Systems Medicine InstituteRan2024 to 2026Enrolled40ConditionsAutism Spectrum Disorder, Wearable DevicesArms14-Day Device Monitoring
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Review
  3. Neurobehavioral Assessment of Sensorimotor Function in Autism Using Smartphone Technology.Autism research : official journal of the International Society for Autism Research · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Wearable sensors in paediatric neurology.Developmental medicine and child neurology · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Rujuta B WilsonSemel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90095, USA.
Sitaram VangalaDepartment of Medicine Statistics Core, David Geffen School of Medicine, 1100 Glendon Avenue, Suite 1820, Los Angeles, CA 90024, USA.
David ElashoffDepartment of Medicine Statistics Core, David Geffen School of Medicine, 1100 Glendon Avenue, Suite 1820, Los Angeles, CA 90024, USA.
Tabitha SafariSemel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90095, USA.
Beth A SmithDepartment of Pediatrics, Keck School of Medicine, Division of Research on Children, Youth, and Families, Developmental Neuroscience and Neurogenetics Program, The Saban Research Institute, Children's Hospital Los Angeles, 4650 Sunset Blvd., MS #71, Los Angeles, CA 90027, USA.ORCID 0000-0003-2531-5394
University of California, Los Angeles · USUniversity of Southern California · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Southern California Clinical and Translational Science InstituteUL1TR001855 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Thomas A Buchanan, Michele D. Kipke · 2016 to 2026
$81.3M
UCLA Center for Translational Research in Neurodevelopment: UC-TRaNU54HD087101 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MCCRACKEN, JAMES T. · 2016 to 2020
$6.5M
Quantification of Infant Motor Development to Predict Risk for Neurodevelopmental DisordersK23HD099275 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WILSON, RUJUTA BHATT · 2020 to 2024
$887k
National Institute of Child Health and Human Development K23HD099275National Institute of Child Health and Human Development U54HD087101-01National Institutes of Neurological Disease 5K12NS09482-03NCATS NIH HHS UL1 TR001855NICHD NIH HHS K23 HD099275SC CTSI (NIH/NCATS) UL1TR001855UCLA Clinical and Translational Science Institute UL1TR001881
6 · The paper itself

Abstract

backgroundMotor dysfunction has been reported as one of the first signs of atypical development in infants at high familial risk for autism spectrum disorder (ASD) (HR infants). However, studies have shown inconsistent results regarding the nature of motor dysfunction and whether it can be predictive of later ASD diagnosis. This is likely because current standardized motor assessments may not identify subtle and specific motor impairments that precede clinically observable motor dysfunction. Quantitative measures of motor development may address these limitations by providing objective evaluation of subtle motor differences in infancy.

methodsWe used Opal wearable sensors to longitudinally evaluate full day motor activity in HR infants, and develop a measure of motion complexity. We focus on complexity of motion because optimal motion complexity is crucial to normal motor development and less complex behaviors might represent repetitive motor behaviors, a core diagnostic symptom of ASD. As proof of concept, the relationship of the motion complexity measure to developmental outcomes was examined in a small set of HR infants.

resultsHR infants with a later diagnosis of ASD show lower motion complexity compared to those that do not. There is a stronger correlation between motion complexity and ASD outcome compared to outcomes of cognitive ability and adaptive skills.

conclusionsObjective measures of motor development are needed to identify characteristics of atypical infant motor function that are sensitive and specific markers of later ASD risk. Motion complexity could be used to track early infant motor development and to discriminate HR infants that go on to develop ASD.

Indexed as

Autism Spectrum DisorderWearable Electronic DevicesCognitionGenetic Predisposition to DiseaseHumansInfantTechnologyautism spectrum disordermotor developmentquantitative measureswearable sensors

Identifiers

PMID33477359
PMCPMC7830886
OpenAlexW3124460321

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.