Evidence map›Paper›PMID 33477346›Full record

ArticleJournal of personalized medicine2021

Single-Pulse Transcranial Magnetic Stimulation-Evoked Potential Amplitudes and Latencies in the Motor and Dorsolateral Prefrontal Cortex among Young, Older Healthy Participants, and Schizophrenia Patients.

Yoshihiro Noda, Mera S Barr, Reza Zomorrodi, Robin F H Cash, Pantelis Lioumis, Robert Chen, Zafiris J Daskalakis, Daniel M Blumberger

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 33 citations in OpenAlex.

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  3. Clinical utility and prospective of TMS-EEG: Updated review from an international expert group.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 5 countries.

Yoshihiro NodaDepartment of Neuropsychiatry, Graduate School of Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan.ORCID 0000-0002-2155-0357
Mera S BarrDepartment of Psychiatry, University of Toronto, Toronto, ON M5T 1R8, Canada.
Reza ZomorrodiTemerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, ON M6J 1H4, Canada.
Robin F H CashMonash Alfred Psychiatry Research Centre, Monash University Central Clinical School and the Alfred, Melbourne 3004, Australia.
Pantelis LioumisDepartment of Neuroscience and Biomedical Engineering, Aalto University School of Science, FI-00076 Espoo, Finland.
Robert ChenDivision of Neurology, Department of Medicine, University of Toronto, Division of Brain, Imaging and Behaviour-Systems Neuroscience, Krembil Research Institute, University Health Network, Toronto, ON M5T 2S8, Canada.ORCID 0000-0002-8371-8629
Zafiris J DaskalakisDepartment of Psychiatry, UC San Diego Health, San Diego, CA 92093, USA.
Daniel M BlumbergerDepartment of Psychiatry, University of Toronto, Toronto, ON M5T 1R8, Canada.
Centre for Addiction and Mental Health · CAAalto University · FIKeio University · JPMonash Alfred Psychiatry Research centre · AUUC San Diego Health System · USUniversity Health Network · CAUniversity of Toronto · CA

Funding

Temerty Centre for Therapeutic Brain Intervention and the Campbell Family Research Institute through the CAMH Foundation, and the Canada Foundation for Innovation None
6 · The paper itself

Abstract

backgroundThe combination of transcranial magnetic stimulation (TMS) with electroencephalography (EEG) allows for non-invasive investigation of cortical response and connectivity in human cortex. This study aimed to examine the amplitudes and latencies of each TMS-evoked potential (TEP) component induced by single-pulse TMS (spTMS) to the left motor (M1) and dorsolateral prefrontal cortex (DLPFC) among healthy young participants (YNG), older participants (OLD), and patients with schizophrenia (SCZ).

methodsWe compared the spatiotemporal characteristics of TEPs induced by spTMS among the groups.

resultsCompared to YNG, M1-spTMS induced lower amplitudes of N45 and P180 in OLD and a lower amplitude of P180 in SCZ, whereas the DLPFC-spTMS induced a lower N45 in OLD. Further, OLD demonstrated latency delays in P60 after M1-spTMS and in N45-P60 over the right central region after left DLPFC-spTMS, whereas SCZ demonstrated latency delays in N45-P60 over the midline and right central regions after DLPFC-spTMS.

conclusionsThese findings suggest that inhibitory and excitatory mechanisms mediating TEPs may be altered in OLD and SCZ. The amplitude and latency changes of TEPs with spTMS may reflect underlying neurophysiological changes in OLD and SCZ, respectively. The spTMS administered to M1 and the DLPFC can probe cortical functions by examining TEPs. Thus, TMS-EEG can be used to study changes in cortical connectivity and signal propagation from healthy to pathological brains.

Indexed as

dorsolateral prefrontal cortexmotor cortexschizophreniaTMS-EEGTMS-evoked potentials

Identifiers

PMID33477346
PMCPMC7830964
OpenAlexW3121231076

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.