Evidence map›Paper›PMID 33477282›Full record

ArticleInternational journal of molecular sciences2021

NMR-Based Structural Characterization of a Two-Disulfide-Bonded Analogue of the FXIIIa Inhibitor Tridegin: New Insights into Structure-Activity Relationships.

Thomas Schmitz, Ajay Abisheck Paul George, Britta Nubbemeyer, Charlotte A Bäuml, Torsten Steinmetzer, Oliver Ohlenschläger, Arijit Biswas, Diana Imhof

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Factor XIII-A: An Indispensable "Factor" in Haemostasis and Wound Healing.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Thomas SchmitzPharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, D-53121 Bonn, Germany.
Ajay Abisheck Paul GeorgePharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, D-53121 Bonn, Germany.
Britta NubbemeyerPharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, D-53121 Bonn, Germany.
Charlotte A BäumlPharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, D-53121 Bonn, Germany.
Torsten SteinmetzerInstitute of Pharmaceutical Chemistry, Philipps University of Marburg, Marbacher Weg 6, 35032 Marburg, Germany.ORCID 0000-0001-6523-4754
Oliver OhlenschlägerLeibniz Institute on Aging-Fritz-Lipmann-Institute, Beutenbergstr. 11, D-07745 Jena, Germany.ORCID 0000-0002-6428-4423
Arijit BiswasInstitute of Experimental Hematology and Transfusion Medicine, University Hospital Bonn, Sigmund-Freud-Str. 25, D-53127 Bonn, Germany.ORCID 0000-0002-4103-5854
Diana ImhofPharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, D-53121 Bonn, Germany.

Funding

Deutsche Stiftung für Herzforschung Imhof
6 · The paper itself

Abstract

The saliva of blood-sucking leeches contains a plethora of anticoagulant substances. One of these compounds derived from

Indexed as

Amino Acid SequenceAnimalsDisulfidesFactor XIIIaFibrinolytic AgentsHumansIsomerismLeechesMagnetic Resonance ImagingMagnetic Resonance SpectroscopyModels, MolecularMolecular Dynamics SimulationSalivary Proteins and PeptidesStructure-Activity RelationshipDisulfidesFactor XIIIaFibrinolytic AgentsSalivary Proteins and Peptidestridegincoagulation cascadecoagulation factor XIIIacysteine-richdisulfide bondsNMR spectroscopypeptide inhibitorstructure analysistransglutaminasetridegin

Identifiers

PMID33477282
PMCPMC7830451

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.