Evidence map›Paper›PMID 33477200›Full record

ArticleJournal of leukocyte biology2021

Myeloid-derived suppressor cells and their association with vaccine immunogenicity in South African infants.

Elvis Kidzeru, Melanie A Gasper, Danica Shao, Paul T Edlefsen, Nicholas Lejarcegui, Enock Havyarimana, Kevin Urdahl, Soren Gantt, Helen Horton, Heather Jaspan and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of leukocyte biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Here, There, and Everywhere: Myeloid-Derived Suppressor Cells in Immunology.Journal of immunology (Baltimore, Md. : 1950) · 2023
    Review
  3. Myeloid-derived suppressor cells and vaccination against pathogens.Frontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 4 countries.

Elvis KidzeruDivision of Immunology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Melanie A GasperSeattle Children's Research Institute, Seattle, Washington, USA.
Danica ShaoFred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Paul T EdlefsenFred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Nicholas LejarceguiUniversity of Washington Department of Global Health, Seattle, Washington, USA.
Enock HavyarimanaDivision of Immunology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Kevin UrdahlSeattle Children's Research Institute, Seattle, Washington, USA.
Soren GanttUniversity of British Columbia Department of Pediatrics and BC Children's Hospital Research Institute, Vancouver, Canada.
Helen HortonUniversity of Washington Department of Global Health, Seattle, Washington, USA.
Heather JaspanDivision of Immunology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Ana GervassiSeattle Children's Research Institute, Seattle, Washington, USA.
University of Cape Town · ZAFred Hutch Cancer Center · USUniversity of Washington · USBC Children's Hospital · CA

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI CONNIE L CELUM · 1988 to 2026
$104.9M
ACADEMIC PEDIATRIC INFECTIOUS DISEASET32HD007233 · NICHD · SEATTLE CHILDREN'S HOSPITAL · PI KEVIN B URDAHL · 1985 to 2026
$6.7M
Myeloid-derived Suppressor cells (MDSC) suppress infant immune responsesR01AI100018 · NIAID · SEATTLE BIOMEDICAL RESEARCH INSTITUTE · PI URDAHL, KEVIN B · 2012 to 2016
$2.2M
Assessing feeding practices, immune activation, and HIV risk in African infantsK08HD069201 · NICHD · SEATTLE CHILDREN'S HOSPITAL · PI JASPAN, HEATHER BERYL · 2011 to 2015
$644k
NIAID NIH HHS P30 AI027757NIAID NIH HHS R01 AI100018NICHD NIH HHS K08 HD069201NICHD NIH HHS T32 HD007233
6 · The paper itself

Abstract

The role of Myeloid-Derived Suppressor Cells (MDSC) in infant immune ontogeny is unknown. Here, we evaluated MDSC frequency and relationship with infant vaccine responses throughout the first year of life in a prospective cohort study. Ninety-one South African infant-mother pairs were enrolled at delivery, and blood samples were collected at 0, 6, 10, and 14 weeks, 6 months, 9 months, and 1 year. MDSC frequencies were quantified, and immune responses to the childhood vaccines Bacillus Calmette-Guérin (BCG), hepatitis B (HepB), and combination diphtheria, tetanus, and pertussis (dTaP) were measured by Ag-specific CD4

Indexed as

Antibodies, BacterialBCG VaccineCohort StudiesDiphtheria-Tetanus-Pertussis VaccineFemaleHepatitis B VaccinesHumansImmunogenicity, VaccineInfantInfant, NewbornMaleMyeloid-Derived Suppressor CellsProspective StudiesSouth AfricaAntibodies, BacterialBCG VaccineDiphtheria-Tetanus-Pertussis VaccineHepatitis B Vaccinescellular immunityinfant immunityMDSCvaccines

Identifiers

PMID33477200
PMCPMC8292449
OpenAlexW3121900225

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.