ArticleInternational immunopharmacology2021
Ozone therapy for the treatment of COVID-19 pneumonia: A scoping review.
Article in International immunopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- CORonavirus-19 mild to moderate pneumonia Management with blood Ozonization in patients with Respiratory failure (CORMOR) multicentric prospective randomized clinical trial.International immunopharmacology · 2021Trial
- Protocols in the therapeutic use of medical ozone: a matter of debate.Medical gas research · 2026Article
- Beyond Paradox: Ozone Therapy as a Hormetic Modulator in Ischemia-Reperfusion Injury - An Update.Cell biochemistry and biophysics · 2025Review
- Therapeutic efficacy of ozonated blood in severe COVID-19 patients: a randomized controlled trial.Frontiers in medicine · 2025Article
- Advances in Electrostatic Plasma Methods for Purification of Airborne Pathogenic Microbial Aerosols: Mechanism, Modeling and Application.Environment & health (Washington, D.C.) · 2024Review
- Physico-Chemical Investigation and Antimicrobial Efficacy of Ozonated Oils: The Case Study of Commercial Ozonated Olive and Sunflower Seed Refined Oils.Molecules (Basel, Switzerland) · 2024Article
- Longitudinal ozone exposure and SARS-CoV-2 infection in late pregnancy: a retrospective cohort study.Frontiers in cellular and infection microbiology · 2024Article
- Ozonated triglyceride protects against septic lethality via preventing the activation of NLRP3 inflammasome.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Article
- Efficacy of ozone therapy on visual evoked potentials in diabetic patients.Diabetology & metabolic syndrome · 2023Article
- Supporting the Aspecific Physiological Defenses of Upper Airways against Emerging SARS-CoV-2 Variants.Pathogens (Basel, Switzerland) · 2023Article
- The Hidden Pandemic of COVID-19-Induced Organizing Pneumonia.Pharmaceuticals (Basel, Switzerland) · 2022Review
- The Mito-Hormetic Mechanisms of Ozone in the Clearance of SARS-CoV2 and in the COVID-19 Therapy.Biomedicines · 2022Review
- Two Natural Flavonoid Substituted Polysaccharides fromMolecules (Basel, Switzerland) · 2022Article
- Article
- SARS-CoV-2 infection and oxidative stress: Pathophysiological insight into thrombosis and therapeutic opportunities.Cytokine & growth factor reviews · 2022Review
- Comments on the optimal use of medical ozone in clinics versus the Ozone High Dose Therapy (OHT) approach.Translational medicine communications · 2022Article
- The biological activity of medical ozone in the hormetic range and the role of full expertise professionals.Frontiers in public health · 2022Article
- Efficacy of ozone adjuvant therapy in COVID-19 patients: A meta-analysis study.Frontiers in medicine · 2022Review
- Insights on the mechanisms of action of ozone in the medical therapy against COVID-19.International immunopharmacology · 2021Review
- Hypothiocyanite and Hypothiocyanite/Lactoferrin Mixture Exhibit Virucidal Activity In Vitro against SARS-CoV-2.Pathogens (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe forms of COVID-19 can evolve into pneumonia, featured by acute respiratory failure due to acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). In viral diseases, the replication of viruses is seemingly stimulated by an imbalance between pro-oxidant and antioxidant activity as well as by the deprivation of antioxidant mechanisms. In COVID-19 pneumonia, oxidative stress also appears to be highly detrimental to lung tissues. Although inhaling ozone (O3) gas has been shown to be toxic to the lungs, recent evidence suggests that its administration via appropriate routes and at small doses can paradoxically induce an adaptive reaction capable of decreasing the endogenous oxidative stress. Ozone therapy is recommended to counter the disruptive effects of severe COVID-19 on lung tissues, especially if administered in early stages of the disease, thereby preventing the progression to ARDS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.