ArticleInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases2021
Clade GR and clade GH isolates of SARS-CoV-2 in Asia show highest amount of SNPs.
Article in Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 38 citations in OpenAlex.
- Longitudinal genomic surveillance of SARS-CoV-2 in a university microcosm reflects global evolutionary trends.Microbiology spectrum · 2026Article
- Factors associated with prolonged viral shedding in COVID-19 infection: A retrospective cohort from Karachi, Pakistan.PloS one · 2025Article
- A comprehensive profile of SARS-CoV-2 variants spreading during the COVID-19 pandemic: a genomic characterization study from Chhattisgarh State, India.Archives of microbiology · 2024Article
- Computational Analysis Predicts Correlations among Amino Acids in SARS-CoV-2 Proteomes.Biomedicines · 2023Article
- Mutations in SARS-CoV-2: Insights on structure, variants, vaccines, and biomedical interventions.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023Review
- Genomic Evidence of Multiple Introductions of SARS-CoV-2 in Mauritania.Bioinformatics and biology insights · 2023Article
- Comparative Analysis of 198 SARS-CoV-2 Genomes from Iran and West Asia, February 2020 to December 2021.Iranian journal of pathology · 2023Article
- Variation analysis of SARS-CoV-2 complete sequences from Iran.Future virology · 2022Article
- Characterisation of SARS-CoV-2 clades based on signature SNPs unveils continuous evolution.Methods (San Diego, Calif.) · 2022Article
- Whole genome sequence analysis showing unique SARS-CoV-2 lineages of B.1.524 and AU.2 in Malaysia.PloS one · 2022Article
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- Feasibility of neighborhood and building scale wastewater-based genomic epidemiology for pathogen surveillance.The Science of the total environment · 2021Article
- The rapid adaptation of SARS-CoV-2-rise of the variants: transmission and resistance.Journal of microbiology (Seoul, Korea) · 2021Review
- Complete genome sequencing and molecular characterization of SARS-COV-2 from COVID-19 cases in Alborz province in Iran.Heliyon · 2021Article
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- SARS-CoV-2 biology and variants: anticipation of viral evolution and what needs to be done.Environmental microbiology · 2021Article
- Phylogenetic and full-length genome mutation analysis of SARS-CoV-2 in Indonesia prior to COVID-19 vaccination program in 2021.Bulletin of the National Research Centre · 2021Article
- Higher entropy observed in SARS-CoV-2 genomes from the first COVID-19 wave in Pakistan.PloS one · 2021Article
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3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clades are monophyletic groups composed of a common ancestor and all its lineal descendants. As the propensity of virulence of a disease depends upon the type of clade the virus belongs to and it causes different fatality rates of disease in different countries, so the clade-wise analysis of SARS-CoV-2 isolates collected from different countries can illuminate the actual evolutionary relationships between them. In this study, 1566 SARS-CoV-2 genome sequences across ten Asian countries are collected, clustered, and characterized based on the clade they belong to. The isolates are compared to the Wuhan reference sequence" hCoV-19/Wuhan/WIV04/19″ to identify the mutations that occurred at different protein regions. Structural changes in amino acids due to mutations lead to functional instability of the proteins. Detailed clade-wise functional assessments are carried out to quantify the stability and vulnerability of the mutations occurring in SARS-CoV-2 genomes which can shade light on personalized prevention and treatment of the disease and encourage towards the invention of clade-specific vaccines.
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