Evidence map›Paper›PMID 33476709›Full record

ArticleAntiviral research2021

Pentostatin antagonizes the antiviral activity of MBX-2168 by inhibiting the biosynthesis of the active compound.

Natalie R Hagen, Marie L Nguyen, John D Williams, Terry L Bowlin, Brian G Gentry

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antiviral research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Natalie R HagenDepartment of Pharmaceutical and Administrative Sciences, College of Pharmacy and Health Sciences, Drake University, Des Moines, IA, 50311, USA.
Marie L NguyenDepartment of Microbiology and Immunology, College of Osteopathic Medicine, Des Moines University, Des Moines, IA, 50312, USA.
John D WilliamsMicrobiotix Inc., Worcester, MA, 01605, USA.
Terry L BowlinMicrobiotix Inc., Worcester, MA, 01605, USA.
Brian G GentryDepartment of Pharmaceutical and Administrative Sciences, College of Pharmacy and Health Sciences, Drake University, Des Moines, IA, 50311, USA. Electronic address: brian.gentry@drake.edu.
Drake University · USMicrobiotix (United States) · USDes Moines University · US

Funding

Novel Methylenecyclopropane Analogues as Anti-Human Herpesvirus 6 and 8 AgentsR44AI082799 · NIAID · MICROBIOTIX, INC · PI BOWLIN, TERRY L. · 2012 to 2014
$3.0M
NIAID NIH HHS R44 AI082799
6 · The paper itself

Abstract

MBX-2168 has a mechanism of action similar to that of acyclovir (ACV) and ganciclovir (GCV), but two unique steps differentiate this drug from ACV/GCV. First, MBX-2168 is, at least partially, phosphorylated by the endogenous cellular kinase TAOK3 to a monophosphate. The second involves the removal of a moiety at the 6-position of MBX-2168-MP by adenosine deaminase like protein-1 (ADAL-1). It has been previously demonstrated that co-incubation with pentostatin (dCF), an ADAL-1 inhibitor, antagonizes the anti-viral activity of MBX-2168. We therefore hypothesize that inhibiting ADAL-1 results in a reduction of active compound produced in virus-infected cells. To test this, we examined the effect dCF has on the conversion of MBX-2168 to a triphosphate in HSV-1 and HCMV-infected cells. Our results demonstrate incubation of MBX-2168 alone or with dCF in HCMV-infected cells resulted in 53.1 ± 0.7 and 39.4 ± 1.5 pmol triphosphate/10

Indexed as

AcyclovirAnimalsAntiviral AgentsCell LineChlorocebus aethiopsCyclopropanesCytomegalovirusCytomegalovirus InfectionsFibroblastsForeskinGanciclovirGuanineHerpes SimplexHerpesvirus 1, HumanHost Microbial InteractionsHumansAcyclovirAntiviral AgentsCyclopropanesGanciclovirGuanineMBX 2168PentostatinPolyphosphatessynguanoltriphosphoric acidCytomegalovirusHerpes simplex virusMethylenecyclopropane nucleoside analogsPentostatin

Identifiers

PMID33476709
PMCPMC7893631
OpenAlexW3123558073

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.