Evidence map›Paper›PMID 33476679›Full record

ArticleToxicology and applied pharmacology2021

Mathermycin, an anti-cancer molecule that targets cell surface phospholipids.

Cuilin Cheng, Haotong Chen, Lingying Tong, Zhenyu Li, Yuehan Yang, Shiyong Wu, Jeffrey S Wiseman, Yong Han

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology and applied pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Mining and Biosynthesis of Bioactive Lanthipeptides From Microorganisms.Frontiers in bioengineering and biotechnology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Cuilin ChengEdison Biotechnology Institute, Ohio University, Athens, OH 45701, USA; School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China.
Haotong ChenEdison Biotechnology Institute, Ohio University, Athens, OH 45701, USA.
Lingying TongEdison Biotechnology Institute, Ohio University, Athens, OH 45701, USA; Department of Chemistry and Biochemistry, Ohio University, Athens, OH 45701, USA.
Zhenyu LiDepartment of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.
Yuehan YangEdison Biotechnology Institute, Ohio University, Athens, OH 45701, USA.
Shiyong WuEdison Biotechnology Institute, Ohio University, Athens, OH 45701, USA; Department of Chemistry and Biochemistry, Ohio University, Athens, OH 45701, USA.
Jeffrey S WisemanEdison Biotechnology Institute, Ohio University, Athens, OH 45701, USA.
Yong HanEdison Biotechnology Institute, Ohio University, Athens, OH 45701, USA. Electronic address: hany@ohio.edu.
Biotechnology Institute · USOhio University · USShandong University · CN

Funding

Molecular mechanisms of cNOS-mediated NF-kappa B activation in regulation of ultraviolet B light-induced photocarcinogenic responsesR01ES030425 · NIEHS · OHIO UNIVERSITY ATHENS · PI WU, SHIYONG · 2019 to 2023
$1.7M
NIEHS NIH HHS R01 ES030425
6 · The paper itself

Abstract

Mathermycin, a lantipeptide isolated from marine actinomycete Marinactinospora thermotolerans, is an antibiotic that has been shown to disrupt bacterial plasma membrane. We now provide evidences that mathermycin can also disrupt cancer, but not normal, cell plasma membranes through targeting phosphatidylethanolamine (PE), which is located only in the inner leaflet of the plasma membrane in normal cells but in both the inner and outer leaflets of the membrane in tumor cells. Our data shows that mathermycin inhibits the metabolic activity and induces mainly necrotic death of all cancer cell lines with EC

Indexed as

3T3 CellsA549 CellsAnimalsAntineoplastic AgentsCell MembraneDrug Resistance, NeoplasmEnergy MetabolismHep G2 CellsHumansMCF-7 CellsMiceNecrosisNeoplasmsPhosphatidylethanolaminesAntineoplastic AgentsphosphatidylethanolaminePhosphatidylethanolaminesAnti-cancerMathermycinPhosphatidylethanolamine

Identifiers

PMID33476679
PMCPMC7928219
OpenAlexW3124635504

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.