ArticleMetabolism: clinical and experimental2021
Reduced brown adipose tissue activity during cold exposure is a metabolic feature of the human thrifty phenotype.
Article in Metabolism: clinical and experimental, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Resting Energy Expenditure and Cold-induced Thermogenesis in Patients With Overt Hyperthyroidism.The Journal of clinical endocrinology and metabolism · 2022Trial
- Reduced adaptive thermogenesis during acute protein-imbalanced overfeeding is a metabolic hallmark of the human thrifty phenotype.The American journal of clinical nutrition · 2021Trial
- Bioactive Phytoconstituents Targeting Energy Expenditure and Appetite to Combat Obesity: A Comprehensive Review.Current nutrition reports · 2026Review
- Thermogenic adipose tissue in older adults with obesity: a narrative review of mechanisms, brown fat resistance, and the translational relevance of exercise and nutrition.Frontiers in nutrition · 2026Review
- Single-nucleus RNA sequencing reveals dynamic changes in the microenvironment of visceral adipose tissue and metabolic characteristics after cold exposure.Frontiers in endocrinology · 2025Article
- Neural circuits of long-term thermoregulatory adaptations to cold temperatures and metabolic demands.Nature reviews. Neuroscience · 2024Review
- Childhood obesity from the genes to the epigenome.Frontiers in endocrinology · 2024Review
- High Fat Diet Suppresses Energy Expenditure Via Neurons in the Brainstem.Neuroscience · 2023Article
- Leveraging GPCR signaling in thermogenic fat to counteract metabolic diseases.Molecular metabolism · 2022Review
- Review
- Energy Balance and Control of Body Weight: Possible Effects of Meal Timing and Circadian Rhythm Dysregulation.Nutrients · 2021Review
- Challenges in tackling energy expenditure as obesity therapy: From preclinical models to clinical application.Molecular metabolism · 2021Review
- Reduced brown adipose tissue activity during cold exposure is a metabolic feature of the human thrifty phenotype.Metabolism: clinical and experimental · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundWe recently demonstrated that thrifty subjects, characterized by a greater decrease in 24 h energy expenditure (24hEE) during short-term fasting, have less capacity for cold-induced thermogenesis (CIT) during 24 h of mild cold exposure.
objectiveAs cold-induced brown adipose tissue activation (CIBA) is a determinant of CIT, we sought to investigate whether thrifty individuals also have reduced CIBA.
methodsTwenty-four healthy subjects (age: 29.8 ± 9.5y, body fat: 27.3 ± 12.4%, 63% male) were admitted to our clinical research unit and underwent two 24hEE assessments in a whole-room indirect calorimeter during energy balance and fasting conditions at thermoneutrality to quantify their degree of thriftiness. Positron emission tomography/computed tomography scans were performed after exposure to 16 °C for 2 h to quantify peak CIBA.
resultsA greater decrease in 24hEE during fasting was associated with lower peak CIBA (r = 0.50, p = 0.01), such that a 100 kcal/day greater reduction in 24hEE related to an average 3.2 g/mL lower peak CIBA.
conclusionOur results indicate that reduced CIBA is a metabolic trait of the thrifty phenotype which might explain reduced CIT capacity and greater predisposition towards weight gain in individuals with a thrifty metabolism.
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