Evidence map›Paper›PMID 33476632›Full record

ArticleLife sciences2021

Protective effect of Rosuvastatin on Azithromycin induced cardiotoxicity in a rat model.

Basma S Mansour, Noha A Salem, Ghada Abdel Kader, Gamal Abdel-Alrahman, Omayma M Mahmoud

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Basma S MansourAnatomy Department, Faculty of Medicine, Suez Canal University, Egypt.
Noha A SalemAnatomy Department, Faculty of Medicine, Suez Canal University, Egypt.
Ghada Abdel KaderAnatomy Department, Faculty of Medicine, Suez Canal University, Egypt.
Gamal Abdel-AlrahmanAnatomy Department, Faculty of Medicine, Suez Canal University, Egypt.
Omayma M MahmoudAnatomy Department, Faculty of Medicine, Suez Canal University, Egypt. Electronic address: omaima_mahmoud@med.suez.edu.eg.
Suez Canal University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsAzithromycin is widely used broad spectrum antibiotic recently used in treatment protocol of COVID-19 for its antiviral and immunomodulatory effects combined with Hydroxychloroquine or alone. Rat models showed that Azithromycin produces oxidative stress, inflammation, and apoptosis of myocardial tissue. Rosuvastatin, a synthetic statin, can attenuate myocardial ischemia with antioxidant and antiapoptotic effects. This study aims to evaluate the probable protective effect of Rosuvastatin against Azithromycin induced cardiotoxicity. MAIN

methodTwenty adult male albino rats were divided randomly into four groups, five rats each control, Azithromycin, Rosuvastatin, and Azithromycin +Rosuvastatin groups. Azithromycin 30 mg/kg/day and Rosuvastatin 2 mg/kg/day were administrated for two weeks by an intragastric tube. Twenty-four hours after the last dose, rats were anesthetized and the following measures were carried out; Electrocardiogram, Blood samples for Biochemical analysis of lactate dehydrogenase (LDH), and creatine phosphokinase (CPK). The animals sacrificed, hearts excised, apical part processed for H&E, immunohistochemical staining, and examined by light microscope. The remaining parts of the heart were collected for assessment of Malondialdehyde (MDA) and Reduced Glutathione (GSH). KEY

findingsThe results revealed that Rosuvastatin significantly ameliorates ECG changes, biochemical, and Oxidative stress markers alterations of Azithromycin. Histological evaluation from Azithromycin group showed marked areas of degeneration, myofibers disorganization, inflammatory infiltrate, and hemorrhage. Immunohistochemical evaluation showed significant increase in both Caspase 3 and Tumor necrosis factor (TNF) immune stain. Rosuvastatin treated group showed restoration of the cardiac muscle fibers in H&E and Immunohistochemical results. SIGNIFICANCE: We concluded that Rosuvastatin significantly ameliorates the toxic changes of Azithromycin on the heart.

Indexed as

AnimalsAnti-Bacterial AgentsAntioxidantsApoptosisAzithromycinCardiotoxicityCOVID-19 Drug TreatmentDisease Models, AnimalGlutathioneHydroxymethylglutaryl-CoA Reductase InhibitorsInflammationMaleMalondialdehydeOxidative StressRatsRats, Sprague-DawleyAnti-Bacterial AgentsAntioxidantsAzithromycinGlutathioneHydroxymethylglutaryl-CoA Reductase InhibitorsMalondialdehydeRosuvastatin CalciumAzithromycinHeartRatRosuvastatin

Identifiers

PMID33476632
PMCPMC7816566
OpenAlexW3124602493

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.