Evidence map›Paper›PMID 33476447›Full record

ArticleJournal of clinical laboratory analysis2021

Untargeted GC/TOFMS unravel metabolic profiles in cerebrospinal fluid of Chinese people living with HIV.

Alim Keram, Ning Pei, Tangkai Qi, Jingna Xun, Yutong Gu, Wenwei Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical laboratory analysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Frontiers in neuroscience · 2024
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Alim KeramDepartment of Neurosurgery, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0003-4671-1927
Ning PeiDepartment of Tuberculosis, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0003-4692-421X
Tangkai QiDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-3771-2488
Jingna XunDepartment of Scientific Research Center, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-6086-6960
Yutong GuDepartment of Tuberculosis and Orthopaedics, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0003-3220-2689
Wenwei LiDepartment of Neurology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-6194-6217
Shanghai Public Health Clinical Center · CN

Funding

Hospital-level project of Shanghai Public Health Clinical Center affiliated to Fudan University
6 · The paper itself

Abstract

backgroundMetabolic syndrome becomes a focus of clinical cares to people living with HIV (PLHIV) globally. This study aimed to explore the metabolic profiles in cerebrospinal fluid (CSF) of Chinese people living with HIV (PLHIV).

methodsCerebrospinal fluid samples from PLHIV and healthy controls were collected from our hospital. Then, the metabolic profiles of CSFs were analyzed PLHIV with healthy individual as the normal controls using the untargeted GC/TOFMS. Following this, kyoto encyclopedia of genes and genomes annotation and pathway analysis were performed to further explore the underlying mechanism of these metabolic alterations in cognitive impairment of PLHIV.

resultsBoth PCA analysis and OPLS-DA had presented that most samples were localized in 95% CI and the gap between control and HIV could significantly separate from each other. Upon this quality control, a total of 82 known metabolites were identified in CSF between PLHIV and healthy controls. Clustering of these metabolites presented that these differentially expressed metabolites could markedly distinguish HIV from healthy controls. Further pathway analyses showed that TCA cycle (citric acid, fumaric acid, lactate, et al.), amino acid (arginine, proline, alanine, aspartate, glutamine, et al.), lipid (cholesterol, butyrate, et al.) metabolisms were significantly changed in CSF of PLHIV, which might affect the cognitive status of PLHIV via affecting neuron energy support, signaling transduction, and neuroinflammation.

conclusionMetabolic profiles were significantly altered in CSF and might play key roles in the etiology of cognitive impairment of PHLIV. Further explore the exact mechanism for these metabolic changes might be useful for cognitive impairment management of PHLIV.

Indexed as

AdultAmino AcidsAsian PeopleCase-Control StudiesCerebrospinal FluidCognitive DysfunctionFemaleGas Chromatography-Mass SpectrometryHIV InfectionsHumansLipidsMaleMetabolic SyndromeMiddle AgedAmino AcidsLipidscerebrospinal fluidHIV-associated neurocognitive disorderhuman immunodeficiency virusmetabonomicuntargeted GC/TOFMS

Identifiers

PMID33476447
PMCPMC7957991
OpenAlexW3122584334

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.