ArticleEpilepsia2021
Focal to bilateral tonic-clonic seizures are associated with widespread network abnormality in temporal lobe epilepsy.
Article in Epilepsia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 8 citations in OpenAlex.
- Rapid hippocampal kindling of mice as a model of sudden unexpected death in temporal lobe epilepsy.Experimental neurology · 2026Article
- Network reorganization of anterograde thalamic connectivity during non-periodic patterned deep brain stimulation.iScience · 2026Article
- Between Patterns and Predictions: Interpretable Latent EEG Representations for Clinical Insights.medRxiv : the preprint server for health sciences · 2026Article
- Thalamo-Lesional Connectivity Signatures of Bilateral Tonic-Clonic Seizures in Focal Cortical Dysplasia-Related Epilepsy.Annals of clinical and translational neurology · 2026Article
- Open diffusion magnetic resonance imaging and connectivity data for epilepsy and surgery: The IDEAS II release.Epilepsia · 2026Article
- Postictal electroencephalographic suppression in generalized tonic-clonic seizures: clinical correlates and predictive factors from a cross-sectional observational study.Epilepsy & behavior reports · 2026Article
- Surgical outcomes for superior frontal sulcus focal cortical dysplasia-related epilepsy.Seizure · 2026Article
- Subtle Hippocampal Subfield Volumetric Alterations in Clinically Diagnosed MRI-Negative Temporal Lobe Epilepsy.Noro psikiyatri arsivi · 2026Article
- Using stereo-electroencephalography data to model the optimal intracranial venous sinus location for an endovascular seizure detection device: A feasibility study.Epilepsia open · 2025Article
- Evaluation of limbic microstructural abnormalities in temporal lobe epilepsy: A neurite orientation distribution and density imaging study.Epilepsia · 2025Article
- Elevated neuroinflammation and region-specific clinical correlates in drug-resistant focal epilepsy.Seizure · 2025Article
- 5-MeO-DMT: An atypical psychedelic with unique pharmacology, phenomenology & risk?Psychopharmacology · 2025Review
- Alternations in morphometric similarity network in mesial temporal epilepsy correlate to neuroinflammatory pathway gene transcriptions.Acta epileptologica · 2025Article
- Article
- Brain Morphometric Alterations in Focal to Bilateral Tonic-Clonic Seizures in Epilepsy Associated With Excitatory/Inhibitory Imbalance.CNS neuroscience & therapeutics · 2024Article
- Cenobamate as an Early Adjunctive Treatment in Drug-Resistant Focal-Onset Seizures: An Observational Cohort Study.CNS drugs · 2024Observational
- Altered structural network in temporal lobe epilepsy with focal to bilateral tonic-clonic seizures.Annals of clinical and translational neurology · 2024Article
- Mapping Functional Connectivity Signatures of Pharmacoresistant Focal Cortical Dysplasia-Related Epilepsy.Annals of neurology · 2024Article
- Edge-wise analysis reveals white matter connectivity associated with focal to bilateral tonic-clonic seizures.Epilepsia · 2024Article
- The sixth sense: how much does interictal intracranial EEG add to determining the focality of epileptic networks?Brain communications · 2024Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveOur objective was to identify whether the whole-brain structural network alterations in patients with temporal lobe epilepsy (TLE) and focal to bilateral tonic-clonic seizures (FBTCS) differ from alterations in patients without FBTCS.
methodsWe dichotomized a cohort of 83 drug-resistant patients with TLE into those with and without FBTCS and compared each group to 29 healthy controls. For each subject, we used diffusion-weighted magnetic resonance imaging to construct whole-brain structural networks. First, we measured the extent of alterations by performing FBTCS-negative (FBTCS-) versus control and FBTCS-positive (FBTCS+) versus control comparisons, thereby delineating altered subnetworks of the whole-brain structural network. Second, by standardizing each patient's networks using control networks, we measured the subject-specific abnormality at every brain region in the network, thereby quantifying the spatial localization and the amount of abnormality in every patient.
resultsBoth FBTCS+ and FBTCS- patient groups had altered subnetworks with reduced fractional anisotropy and increased mean diffusivity compared to controls. The altered subnetwork in FBTCS+ patients was more widespread than in FBTCS- patients (441 connections altered at t > 3, p < .001 in FBTCS+ compared to 21 connections altered at t > 3, p = .01 in FBTCS-). Significantly greater abnormalities-aggregated over the entire brain network as well as assessed at the resolution of individual brain areas-were present in FBTCS+ patients (p < .001, d = .82, 95% confidence interval = .32-1.3). In contrast, the fewer abnormalities present in FBTCS- patients were mainly localized to the temporal and frontal areas. SIGNIFICANCE: The whole-brain structural network is altered to a greater and more widespread extent in patients with TLE and FBTCS. We suggest that these abnormal networks may serve as an underlying structural basis or consequence of the greater seizure spread observed in FBTCS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.