ArticlePLoS computational biology2021
Modelling thalamocortical circuitry shows that visually induced LTP changes laminar connectivity in human visual cortex.
Article in PLoS computational biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Inter-individual variability in neural response to low doses of LSD.Translational psychiatry · 2024Trial
- Modulation of long-term potentiation following microdoses of LSD captured by thalamo-cortical modelling in a randomised, controlled trial.BMC neuroscience · 2024Trial
- Frequency-dependent photic modulation of wakeful consolidation in visual learning.Nature communications · 2025Article
- Acute exercise as a modifier of neocortical plasticity and aperiodic activity in the visual cortex.Scientific reports · 2023Article
- Changes in Visual Long-Term Potentiation Show Preserved Cyclicity in Human Females Taking Combined Oral Contraceptives.Neuroendocrinology · 2023Article
- Flicker light stimulation induces thalamocortical hyperconnectivity with LGN and higher-order thalamic nuclei.Imaging neuroscience (Cambridge, Mass.) · 2023Article
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Neuroplasticity is essential to learning and memory in the brain; it has therefore also been implicated in numerous neurological and psychiatric disorders, making measuring the state of neuroplasticity of foremost importance to clinical neuroscience. Long-term potentiation (LTP) is a key mechanism of neuroplasticity and has been studied extensively, and invasively in non-human animals. Translation to human application largely relies on the validation of non-invasive measures of LTP. The current study presents a generative thalamocortical computational model of visual cortex for investigating and replicating interlaminar connectivity changes using non-invasive EEG recording of humans. The model is combined with a commonly used visual sensory LTP paradigm and fit to the empirical EEG data using dynamic causal modelling. The thalamocortical model demonstrated remarkable accuracy recapitulating post-tetanus changes seen in invasive research, including increased excitatory connectivity from thalamus to layer IV and from layer IV to II/III, established major sites of LTP in visual cortex. These findings provide justification for the implementation of the presented thalamocortical model for ERP research, including to provide increased detail on the nature of changes that underlie LTP induced in visual cortex. Future applications include translating rodent findings to non-invasive research in humans concerning deficits to LTP that may underlie neurological and psychiatric disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.