Evidence map›Paper›PMID 33476211›Full record

ArticleMolecular biology of the cell2021

The TIM22 complex mediates the import of sideroflexins and is required for efficient mitochondrial one-carbon metabolism.

Thomas D Jackson, Daniella H Hock, Kenji M Fujihara, Catherine S Palmer, Ann E Frazier, Yau C Low, Yilin Kang, Ching-Seng Ang, Nicholas J Clemons, David R Thorburn and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Molecular biology of the cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Article
  3. Genetic ablation ofiScience · 2026
    Article
  4. From the cytosol to the inner membrane: biogenesis of the mitochondrial carrier family.Protein science : a publication of the Protein Society · 2026
    Review
  5. Review
  6. Review
  7. Mitochondrial DNA depletion syndrome and its cardiac complication.Frontiers in cardiovascular medicine · 2025
    Review
  8. Cardiac Involvement in Mitochondrial Disorders.Current heart failure reports · 2023
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Acylglycerol Kinase-Targeted Therapies in Oncology.Frontiers in cell and developmental biology · 2021
    Review
  19. Review
  20. Targeting and Insertion of Membrane Proteins in Mitochondria.Frontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Thomas D JacksonDepartment of Biochemistry and Pharmacology and The Bio21 Molecular Science and Biotechnology Institute.
Daniella H HockDepartment of Biochemistry and Pharmacology and The Bio21 Molecular Science and Biotechnology Institute.
Kenji M FujiharaSir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria 3010, Australia.
Catherine S PalmerDepartment of Biochemistry and Pharmacology and The Bio21 Molecular Science and Biotechnology Institute.
Ann E FrazierMurdoch Children's Research Institute and.
Yau C LowMurdoch Children's Research Institute and.
Yilin KangDepartment of Biochemistry and Pharmacology and The Bio21 Molecular Science and Biotechnology Institute.
Ching-Seng AngBio21 Mass Spectrometry and Proteomics Facility, The University of Melbourne, Parkville, Victoria 3010, Australia.
Nicholas J ClemonsSir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria 3010, Australia.
David R ThorburnMurdoch Children's Research Institute and.
David A StroudDepartment of Biochemistry and Pharmacology and The Bio21 Molecular Science and Biotechnology Institute.
Diana StojanovskiDepartment of Biochemistry and Pharmacology and The Bio21 Molecular Science and Biotechnology Institute.
The University of Melbourne · AUBiotechnology Institute · USRoyal Children's Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acylglycerol kinase (AGK) is a mitochondrial lipid kinase that contributes to protein biogenesis as a subunit of the TIM22 complex at the inner mitochondrial membrane. Mutations in

Indexed as

CarbonCarrier ProteinsCell Culture TechniquesHumansMCF-7 CellsMembrane ProteinsMembrane Transport ProteinsMitochondriaMitochondrial MembranesMitochondrial Membrane Transport ProteinsMitochondrial Precursor Protein Import Complex ProteinsMitochondrial ProteinsMutationPhenotypePhosphotransferases (Alcohol Group Acceptor)Primary Cell Cultureacylglycerol kinaseCarbonCarrier ProteinsMembrane ProteinsMembrane Transport ProteinsMitochondrial Membrane Transport ProteinsMitochondrial Precursor Protein Import Complex ProteinsMitochondrial ProteinsPhosphotransferases (Alcohol Group Acceptor)TIM22 protein, human

Identifiers

PMID33476211
PMCPMC8101445
OpenAlexW3126119156

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.