ArticleAngewandte Chemie (International ed. in English)2021
Development of High-Performance Pyrimidine Nucleoside and Oligonucleotide Diarylethene Photoswitches.
Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 34 citations in OpenAlex.
- Fully Reversible Regulation of 8-17 DNAzyme Activity Using Nucleoside-Based Diarylethenes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Fatigue-Resistant Dithienylarene Photoswitches with Acid-Regulated Thermal Ring Opening.ACS omega · 2026Article
- Designing Reversible Photoswitching Azobenzene-Modified Nucleotide for Controlling Biological Function.Journal of the American Chemical Society · 2025Article
- Pd(ii)-catalyzed enantioselective C-H olefination and photoregulation of sterically hindered diarylethenes.Chemical science · 2024Article
- Ion valence-gated photochromism of an aza-crowned diarylethene.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2024Article
- Enhancing tetraphenylethene cyclization as photoswitch.Smart molecules : open access · 2023Article
- Controlling the Structure and Morphology of Organic Nanofilaments Using External Stimuli.ACS nanoscience Au · 2023Article
- A DNA-Based Two-Component Excitonic Switch Utilizing High-Performance Diarylethenes.Angewandte Chemie (International ed. in English) · 2022Article
- Photochemical modifications for DNA/RNA oligonucleotides.RSC advances · 2022Review
- Development of Red-Shifted and Fluorogenic Nucleoside and Oligonucleotide Diarylethene Photoswitches.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- "Click-switch" - one-step conversion of organic azides into photochromic diarylethenes for the generation of light-controlled systems.Chemical science · 2021Article
- Development of High-Performance Pyrimidine Nucleoside and Oligonucleotide Diarylethene Photoswitches.Angewandte Chemie (International ed. in English) · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nucleosidic and oligonucleotidic diarylethenes (DAEs) are an emerging class of photochromes with high application potential. However, their further development is hampered by the poor understanding of how the chemical structure modulates the photochromic properties. Here we synthesized 26 systematically varied deoxyuridine- and deoxycytidine-derived DAEs and analyzed reaction quantum yields, composition of the photostationary states, thermal and photochemical stability, and reversibility. This analysis identified two high-performance photoswitches with near-quantitative, fully reversible back-and-forth switching and no detectable thermal or photochemical deterioration. When incorporated into an oligonucleotide with the sequence of a promotor, the nucleotides maintained their photochromism and allowed the modulation of the transcription activity of T7 RNA polymerase with an up to 2.4-fold turn-off factor, demonstrating the potential for optochemical control of biological processes.
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