Evidence map›Paper›PMID 33476070›Full record

ArticleThoracic cancer2021

Immune checkpoint inhibitors-induced eosinophilic pneumonia: A case report.

Kanako Hara, Kei Yamasaki, Masahiro Tahara, Rieko Kimuro, Yudai Yamaguchi, Yu Suzuki, Hiroki Kawabata, Toshinori Kawanami, Naohiro Fujimoto, Kazuhiro Yatera

Open access · goldAbstract readCase Reports
In one paragraph

Article in Thoracic cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Kanako HaraDepartment of Respiratory Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Kei YamasakiDepartment of Respiratory Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.ORCID 0000-0003-1876-3287
Masahiro TaharaDepartment of Respiratory Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Rieko KimuroDepartment of Urology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Yudai YamaguchiDepartment of Respiratory Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Yu SuzukiDepartment of Respiratory Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Hiroki KawabataDepartment of Respiratory Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Toshinori KawanamiDepartment of Respiratory Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Naohiro FujimotoDepartment of Urology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Kazuhiro YateraDepartment of Respiratory Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
University of Occupational and Environmental Health Japan · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 78-year-old male with renal cell carcinoma was treated with combined immunotherapy of nivolumab and ipilimumab. After four courses of the treatment, a chest computed tomography (CT) revealed newly formed ground-glass opacities (GGOs) in both the lower lung lobes; drug-induced pneumonia was speculated. Eosinophil counts were elevated in both peripheral blood and bronchoalveolar lavage fluid. Both the immune checkpoint inhibitors (ICIs) were discontinued, following which the chest CT findings improved. Based on these findings, a diagnosis of ICI-induced eosinophilic pneumonia was made. Hence, clinicians should be wary of the risk of eosinophilic pneumonia during ICI-anticancer therapy.

Indexed as

AgedHumansImmune Checkpoint InhibitorsMalePulmonary EosinophiliaImmune Checkpoint Inhibitorseosinophilic pneumoniaimmune checkpoint inhibitorimmune-related adverse eventipilimumabnivolumab

Identifiers

PMID33476070
PMCPMC7919115
OpenAlexW3125131368

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.