Evidence map›Paper›PMID 33475982›Full record

ArticleMetabolic brain disease2021

MicroRNA-125b alleviates hydrogen-peroxide-induced abnormal mitochondrial dynamics in HT22 cells by inhibiting p53.

Yan Huang, Songyun Deng, Yuhang Ai, Yunan Mo, Wenchao Li, Qianyi Peng, Li Huang, Lina Zhang

Abstract read
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In one paragraph

Article in Metabolic brain disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yan HuangDepartment of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, People's Republic of China, 410008.
Songyun DengDepartment of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, People's Republic of China, 410008.
Yuhang AiDepartment of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, People's Republic of China, 410008.
Yunan MoDepartment of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, People's Republic of China, 410008.
Wenchao LiDepartment of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, People's Republic of China, 410008.
Qianyi PengDepartment of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, People's Republic of China, 410008.
Li HuangDepartment of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, People's Republic of China, 410008.
Lina ZhangDepartment of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, People's Republic of China, 410008. zln7095@csu.edn.cn.
Xiangya Hospital Central South University · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Micro-RNA125b (miR-125b) and tumor protein p53 (p53) are involved in the regulation of mitochondrial dynamics; however, the mechanism of their possible interaction during oxidative stress remains unclear. In this study, we investigated the role and mechanism of miR-125b and p53 in oxidative stress-induced mitochondrial damage in immortalized mouse hippocampal HT22 cells. Following stimulation with H

Indexed as

AnimalsCell Line, TransformedCell SurvivalHydrogen PeroxideMiceMicroRNAsMitochondrial DynamicsTumor Suppressor Protein p53Hydrogen PeroxideMicroRNAsMirn125 microRNA, mouseTumor Suppressor Protein p53Micro-RNA 125bMitochondrial dynamicsOxidative stressp53

Identifiers

PMID33475982
OpenAlexW3121831136

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.