Evidence map›Paper›PMID 33475971›Full record

ArticleNeuromolecular medicine2021

Lipidomic Analysis of Postmortem Prefrontal Cortex Phospholipids Reveals Changes in Choline Plasmalogen Containing Docosahexaenoic Acid and Stearic Acid Between Cases With and Without Alzheimer's Disease.

Yurika Otoki, Shunji Kato, Kiyotaka Nakagawa, Danielle J Harvey, Lee-Way Jin, Britany N Dugger, Ameer Y Taha

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Neuromolecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Yurika OtokiDepartment of Food Science and Technology, College of Agriculture and Environmental Sciences, University of California Davis, One Shields Avenue, Davis, CA, 95616, USA.
Shunji KatoFood and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Miyagi, Japan.
Kiyotaka NakagawaFood and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Miyagi, Japan.
Danielle J HarveyDepartment of Public Health Sciences, University of California - Davis, Davis, CA, USA.
Lee-Way JinDepartment of Pathology, University of California - Davis School of Medicine, Davis, CA, USA.
Britany N DuggerDepartment of Pathology, University of California - Davis School of Medicine, Davis, CA, USA.
Ameer Y TahaDepartment of Food Science and Technology, College of Agriculture and Environmental Sciences, University of California Davis, One Shields Avenue, Davis, CA, 95616, USA. ataha@ucdavis.edu.ORCID 0000-0003-4611-7450
University of California, Davis · USTohoku University · JP

Funding

UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 1991 to 2020
$28.3M
NIA NIH HHS P30 AG010129
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a progressive and incurable brain disorder that has been associated with structural changes in brain phospholipids (PLs), including diacyl species and ether-linked PLs known as plasmalogens. Most studies have characterized total changes in brain PL pools (e.g., choline plasmalogens), particularly in prefrontal cortex, but detailed and quantitative information on the molecular PL species impacted by the disease is limited. In this study, we used a comprehensive mass-spectrometry method to quantify diacyl and plasmalogen species, alkyl synthetic precursors of plasmalogens, and lysophospholipid degradation products of diacyl and plasmalogen PLs, in postmortem samples of prefrontal cortex from 21 AD patients and 20 age-matched controls. Total PLs were also quantified with gas-chromatography analysis of bound fatty acids following thin layer chromatography isolation. There was a significant 27% reduction in the concentration (nmol/g wet weight) of choline plasmalogen containing stearic acid (alkenyl group) and docosahexaenoic acid in AD compared to controls. Stearic acid concentration in total PLs was reduced by 26%. Our findings suggest specific changes in PLs containing stearic acid and docosahexaenoic acid in AD prefrontal cortex, highlighting structural and turnover PL pathways that could be targeted.

Indexed as

LipidomicsPostmortem ChangesAgedAged, 80 and overAlzheimer DiseaseCase-Control StudiesChromatography, High Pressure LiquidDocosahexaenoic AcidsFatty AcidsFemaleHumansLysophospholipidsMaleModels, MolecularPhospholipidsPlasmalogenscholine plasmalogensDocosahexaenoic AcidsFatty AcidsLysophospholipidsPhospholipidsPlasmalogensstearic acidStearic AcidsAlkyl-acyl phospholipidsAlzheimer’s diseaseLipidsLysophospholipidsPlasmalogensPrefrontal cortex

Identifiers

PMID33475971
OpenAlexW3124060074

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.