Evidence map›Paper›PMID 33475891›Full record

ArticleAAPS PharmSciTech2021

Exploratory Study on Lercanidipine Hydrochloride Polymorphism: pH-Dependent Solubility Behavior and Simulation of its Impact on Pharmacokinetics.

Ilia Alekseevich Repin, Raimar Loebenberg, John DiBella, António C L Conceição, Manuel E Minas da Piedade, Humberto G Ferraz, Michele G Issa, Nadia A Bou-Chacra, Catharine F M Ermida, Gabriel L B de Araujo

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in AAPS PharmSciTech, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Ilia Alekseevich RepinDepartamento de Farmácia, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, São Paulo, 05508-000, Brazil.
Raimar LoebenbergFaculty of Pharmacy & Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada.
John DiBellaSimulations Plus, Inc., 42505 10th Street West, Lancaster, California, 93534, USA.
António C L ConceiçãoCentro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, 1049-001, Lisboa, Portugal.
Manuel E Minas da PiedadeCentro de Química Estrutural, Faculdade de Ciências, Universidade de Lisboa, 1749-016, Lisboa, Portugal. memp@fc.ul.pt.
Humberto G FerrazDepartamento de Farmácia, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, São Paulo, 05508-000, Brazil.
Michele G IssaDepartamento de Farmácia, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, São Paulo, 05508-000, Brazil.
Nadia A Bou-ChacraDepartamento de Farmácia, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, São Paulo, 05508-000, Brazil.
Catharine F M ErmidaDepartamento de Farmácia, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, São Paulo, 05508-000, Brazil.
Gabriel L B de AraujoDepartamento de Farmácia, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, São Paulo, 05508-000, Brazil. gabriel.araujo@usp.br.
Universidade de São Paulo · BRUniversity of Lisbon · PTSimulations Plus (United States) · USUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This work describes an exploratory experimental and in silico study of the influence of polymorphism, particle size, and physiology on the pharmacokinetics of lercanidipine hydrochloride (LHC). Equilibrium and kinetic solubility studies were performed on LHC forms I and II, as a function of pH and buffer composition. GastroPlus® was used to evaluate the potential effect of solubility differences due to polymorphism, particle size, and physiological conditions, on the drug pharmacokinetics. The results indicated that solubilities of LHC polymorphs are strongly dependent on the composition and pH of the buffer media. The concentration ratio (C

Indexed as

Biological AvailabilityDihydropyridinesHumansHydrogen-Ion ConcentrationParticle SizeSolubilityDihydropyridineslercanidipinelercanidipine hydrochloridePBPK simulationpharmacokineticspolymorphismsolubility

Identifiers

PMID33475891
OpenAlexW3125757947

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.