ReviewBreast cancer research and treatment2021
Body composition and breast cancer risk and treatment: mechanisms and impact.
Review in Breast cancer research and treatment, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06618690 (Efficacy of a Supervised Exercise Program on Pain, Physical Function, and Quality of Life in Breast Cancer Survivors), which is not on this map. Cited by 62 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of a Supervised Exercise Program on Pain, Physical Function, and Quality of Life in Breast Cancer Survivors: Protocol for a Randomized Clinical Trial
Who cites it
62 citing papers in PubMed, 3 syntheses or guidelines pooled it, 95 citations in OpenAlex.
- The effects of aerobic and resistance training across eight cancer types: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Pooled it
- Prevalence and clinical implications of sarcopenia in breast cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Pooled it
- The prognostic value of skeletal muscle mass and density in breast cancer: a systematic review and meta-analysis.Future oncology (London, England) · 2024Pooled it
- Mindful eating as a supportive intervention for breast cancer survivors: a pilot randomized controlled trial.Breast cancer (Tokyo, Japan) · 2026Trial
- Abdominal visceral and subcutaneous adipose tissue associations with postmenopausal breast cancer incidence.JNCI cancer spectrum · 2025Trial
- Physical activity and/or dietary intervention in overweight or obese breast cancer survivors: results of the InForma randomized trial.Journal of cancer survivorship : research and practice · 2024Trial
- Associations of body composition with neoadjuvant chemotherapy response, toxicity, and prognosis in breast cancer: a scoping review.Cancer chemotherapy and pharmacology · 2026Article
- Treatment Decision-making and Weight Loss Expectations for Current Obesity Treatment.Current obesity reports · 2026Review
- Overall and central adiposity and risk of contralateral breast cancer: The California Breast Cancer Survivorship Consortium.International journal of cancer · 2026Article
- Visceral and Subcutaneous Fat Deposits Exhibit Distinct Roles in the Initiation and Progression of Breast Cancer.Breast cancer (Dove Medical Press) · 2026Article
- The impact of sarcopenia and body mass index on treatment toxicity and survival in patients with extranodal natural killer/T-cell lymphoma: a retrospective analysis.Frontiers in oncology · 2026Article
- Skeletal Muscle Mass in Women With Breast Cancer: Evaluation of Agreement Between Different Methods.Journal of nutrition and metabolism · 2026Article
- MRI-Derived Body Composition and Breast Cancer Risk in Postmenopausal Women: UK Biobank Study.Cancers · 2025Article
- Review
- A pilot study of pre-diagnosis dietary patterns and lifestyle factors in physically active and inactive women with breast cancer.Scientific reports · 2025Article
- Sarcopenic obesity exacerbates gastric cancer prognosis via increased intermuscular and visceral fat accumulation.European journal of medical research · 2025Observational
- Factors associated with fatigue in women with breast cancer before starting treatment: a cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Triage tools to inform the prioritisation of physical health services following a diagnosis of cancer: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Risk of sarcopenia in women with breast cancer: a comparative analysis of screening tools.BMC cancer · 2025Observational
- Metabolic and transcriptional effects of bazedoxifene/conjugated estrogens in a model of obesity-associated breast cancer risk.JCI insight · 2025Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
purposeThe purpose of this review is to clarify the association of body composition with breast cancer risk and treatment, including physiological mechanisms, and to elucidate strategies for overcoming unfavorable body composition changes that relate to breast cancer progression.
methodsWe have summarized updated knowledge regarding the mechanism of the negative association of altered body composition with breast cancer risk and treatment. We also review strategies for reversing unfavorable body composition based on the latest clinical trial results.
resultsBody composition changes in patients with breast cancer typically occur during menopause or as a result of chemotherapy or endocrine therapy. Dysfunction of visceral adipose tissue (VAT) in the setting of obesity underlies insulin resistance and chronic inflammation, which can lead to breast cancer development and progression. Insulin resistance and chronic inflammation are also observed in patients with breast cancer who have sarcopenia or sarcopenic obesity. Nutritional support and a personalized exercise program are the fundamental interventions for reversing unfavorable body composition. Other interventions that have been explored in specific situations include metformin, testosterone, emerging agents that directly target the adipocyte microenvironment, and bariatric surgery.
conclusionsA better understanding of the biology of body composition phenotypes is key to determining the best intervention program for patients with breast cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.