ArticleJournal of materials science. Materials in medicine2021
The effect of synthetic bone graft substitutes on bone formation in rabbit calvarial defects.
Article in Journal of materials science. Materials in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Harnessing and Optimizing α-TCP for Oral Tissue Engineering and Regenerative Dentistry.International dental journal · 2026Review
- Physicochemical Characterization, Cytotoxicity, and In Vivo Evaluation of a Hydroxyapatite-Silver Composite for Bone Regeneration.BioMed research international · 2026Article
- Bi-Layered Biphasic Calcium Phosphate Bone Substitute to Improve Bone Formation in Lateral Jaw Defects Applying the Principle of Guided Bone Regeneration (GBR)-A Pre-Clinical Randomized Controlled Study.Clinical oral implants research · 2025Article
- Bone regeneration and biosorption patterns of different bone substitutes: anJournal of periodontal & implant science · 2025Article
- Combined use of deproteinized bovine bone mineral and α-tricalcium phosphate using gelatin carriers.BMC oral health · 2025Article
- Dual-functional 3D-printed porous bioactive scaffold enhanced bone repair by promoting osteogenesis and angiogenesis.Materials today. Bio · 2024Article
- Addition of Synthetic Biomaterials to Deproteinized Bovine Bone Mineral (DBBM) for Bone Augmentation-A Preclinical In Vivo Study.International journal of molecular sciences · 2022Article
- Innovative Concepts and Recent Breakthrough for Engineered Graft and Constructs for Bone Regeneration: A Literature Systematic Review.Materials (Basel, Switzerland) · 2022Review
- Impact of Cross-Linking of Collagen Matrices on Tissue Regeneration in a Rabbit Calvarial Bone Defect.Materials (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to evaluate the influence of the intensity of the biomimetic hydroxyapatite (HA) coating of α-tricalcium phosphate (α-TCP) on biomaterial degradation and bone formation. Twenty-four female NZW rabbits of approximately 12 weeks of age were used. Critical size defects were randomly treated with 3%:97% HA:α-TCP (BBCP1), 12%:88% HA:α-TCP (BBCP2), and 23%:77% HA:α-TCP (BBCP3), respectively or sham. All defects were covered with a resorbable collagen membrane. Animals were euthanized after 3 and 12 weeks of healing and samples were investigated by micro-CT and histologic analysis. Ingrowth of newly formed woven bone from the original bone at 3-week healing period was observed in all samples. At the 12-week healing period, the new bone in the peripheral area was mainly lamellar and in the central region composed of both woven and lamellar bone. New bony tissue was found on the surface of all three types of granules and at the interior of the BBCP1 granules. Samples with 3% HA showed significantly less residual biomaterial in comparison to the other two groups. Furthermore, BBCP1 significantly promoted new bone area as compared to other three groups and more bone volume as compared to the control. Within its limitations, this study indicated the highest degradation rate in case of BBCP1 concomitant with the highest rate of bone formation. Hence, formation of new bone can be affected by the level of biomimetic HA coating of α-TCP.
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