ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2021
The Association of Muscle Mass Measured by D3-Creatine Dilution Method With Dual-Energy X-Ray Absorptiometry and Physical Function in Postmenopausal Women.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
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- The impact of lifestyle-based weight loss in older adults with obesity on muscle and bone health: a balancing act.Obesity (Silver Spring, Md.) · 2025Review
- What Is 'Muscle Health'? A Narrative Review and Conceptual Framework.Journal of functional morphology and kinesiology · 2025Review
- Novel Algorithm to Estimate Fat-Free Muscle Volumes in Women Using the Urinary Deuterated-Creatine Dilution Method.Journal of cachexia, sarcopenia and muscle · 2025Article
- Novel multimodal intervention for surgical prehabilitation on functional recovery and muscle characteristics in patients with non-small cell lung cancer: study protocol for a randomised controlled trial (MMP-LUNG).BMJ open respiratory research · 2025Article
- GDF8 and activin A blockade protects against GLP-1-induced muscle loss while enhancing fat loss in obese male mice and non-human primates.Nature communications · 2025Article
- Association of body composition measures to muscle strength using DXA, DScientific reports · 2025Article
- Change in D3Cr muscle mass in oldest old men and its association with changes in grip strength and walking speed.PloS one · 2025Article
- Relationship of psychotropic medication use with physical function among postmenopausal women.GeroScience · 2024Article
- Associations Between D3Cr Muscle Mass and Magnetic Resonance Thigh Muscle Volume With Strength, Power, Physical Performance, Fitness, and Limitations in Older Adults in the SOMMA Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Estimating Muscle Mass Using D3-Creatine Dilution: A Narrative Review of Clinical Implications and Comparison With Other Methods.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Review
- DCalcified tissue international · 2024Review
- Article
- Compartmental analysis: a new approach to estimate protein breakdown and meal response in health and critical illness.Frontiers in nutrition · 2024Review
- D3-creatine dilution, computed tomography and dual-energy X-ray absorptiometry for assessing myopenia and physical function in colon cancer: A cross-sectional study.Journal of cachexia, sarcopenia and muscle · 2023Article
- Associations between DmedRxiv : the preprint server for health sciences · 2023Article
- The paradox of obesity with normal weight; a cross-sectional study.Frontiers in nutrition · 2023Article
- Association of sarcopenia with important health conditions among community-dwelling Asian women.PloS one · 2023Article
- DJournal of cachexia, sarcopenia and muscle · 2022Review
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundThe D3-creatine (D3Cr) dilution method provides a direct measure of skeletal muscle. The aim of this study was to compare the association of D3Cr muscle mass with lean body mass (LBM) measured by dual-energy x-ray absorptiometry (DXA) and examine its relation with physical function in postmenopausal women.
methodsSeventy-four community-dwelling women (mean age 82.3 ± 5.4) participated in this pilot study from the Buffalo, New York clinical site of the Women's Health Initiative (WHI). Participants attended a clinic visit which included anthropometric measures, blood draw, DXA scan, measures of physical function, and initiated the D3Cr protocol. Physical function was evaluated using hand grip strength, short physical performance battery (SPPB), and RAND-36 physical function scale. Descriptive statistics and logistic regression models were used to examine the associations of D3Cr muscle mass with functional outcomes.
resultsD3-creatine muscle mass was moderately correlated with DXA LBM (r = 0.50) and DXA appendicular lean mass (ALM) (r = 0.50). Individuals with high D3Cr muscle mass (%) had higher physical function compared to individuals with low muscle mass (%), indicated by high scores on SPPB (odds ratio [OR] = 5.24; 95% confidence interval [CI]: 1.40, 19.58). We observed stronger relationships between high D3Cr and physical function than either DXA LBM (OR = 3.40; 95% CI: 0.88, 13.11) or DXA ALM (OR = 4.15; 95% CI: 1.10, 15.68) and physical function.
conclusionsOur findings provide strong preliminary data for the associations of D3Cr muscle mass with measures of physical function in older women. These findings support and extend prior work on D3Cr muscle mass in older men.
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