ArticleJournal of experimental botany2021
A genome-wide association study reveals cytokinin as a major component in the root defense responses against Ralstonia solanacearum.
Article in Journal of experimental botany, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Pathogenicity and virulence ofVirulence · 2026Review
- Beyond Resistance Genes: Silencing Susceptibility.International journal of molecular sciences · 2026Review
- Exploring the Potential of Plant Cytokinins Against Common Human Pathogens: In Vitro Assessment and In Silico Insights.Plants (Basel, Switzerland) · 2025Article
- A Genome-Wide Association Screen for Genes Affecting Leaf Trichome Development and Epidermal Metal Accumulation in Arabidopsis.Plant, cell & environment · 2025Article
- The 14-3-3 protein CaTFT7 interacts with transcription factor CaHDZ27 to positively regulate pepper immunity againstHorticulture research · 2025Article
- Salicylic acid: The roles in plant immunity and crosstalk with other hormones.Journal of integrative plant biology · 2025Review
- Identification of stress-alleviating strains from the core drought-responsive microbiome of Arabidopsis ecotypes.The ISME journal · 2025Article
- Key mechanisms of plant-Frontiers in microbiology · 2025Review
- Cytokinin Plays a Multifaceted Role in Ralstonia solanacearum-Triggered Plant Disease Development.Molecular plant pathology · 2024Article
- Time Course RNA-seq Reveals Soybean Responses against Root-Lesion Nematode and Resistance Players.Plants (Basel, Switzerland) · 2022Article
- Study of natural diversity in response to a key pathogenicity regulator of Ralstonia solanacearum reveals new susceptibility genes in Arabidopsis thaliana.Molecular plant pathology · 2022Article
- Weighted Gene Co-Expression Analysis Network-Based Analysis on the Candidate Pathways and Hub Genes in Eggplant Bacterial Wilt-Resistance: A Plant Research Study.International journal of molecular sciences · 2021Article
- Exploring the genic resources underlying metabolites through mGWAS and mQTL in wheat: From large-scale gene identification and pathway elucidation to crop improvement.Plant communications · 2021Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial wilt caused by the soil-borne pathogen Ralstonia solancearum is economically devastating, with no effective methods to fight the disease. This pathogen invades plants through their roots and colonizes their xylem, clogging the vasculature and causing rapid wilting. Key to preventing colonization are the early defense responses triggered in the host's root upon infection, which remain mostly unknown. Here, we have taken advantage of a high-throughput in vitro infection system to screen natural variability associated with the root growth inhibition phenotype caused by R. solanacearum in Arabidopsis during the first hours of infection. To analyze the genetic determinants of this trait, we have performed a genome-wide association study, identifying allelic variation at several loci related to cytokinin metabolism, including genes responsible for biosynthesis and degradation of cytokinin. Further, our data clearly demonstrate that cytokinin signaling is induced early during the infection process and cytokinin contributes to immunity against R. solanacearum. This study highlights a new role for cytokinin in root immunity, paving the way for future research that will help in understanding the mechanisms underpinning root defenses.
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Registered trials
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