ArticleBone & joint research2021
Antibiofilm efficacy of focused high-energy extracorporeal shockwaves and antibiotics in vitro.
Article in Bone & joint research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 19 citations in OpenAlex.
- Investigation of shockwave treatment for disruption of bacterial biofilm on tubular structure.Scientific reports · 2025Article
- Low-energy shock waves improve the bacterial detection of Staphylococcus aureus biofilms on polyethylene.Scientific reports · 2025Article
- Evaluating the efficacy of low-energy shock waves in treating uropathogenic E. coli.International urology and nephrology · 2025Article
- Shock Wave-Activated Silver-Loaded Biopolymer Implant Coating EliminatesPharmaceutics · 2023Article
- On-Demand Release of Anti-Infective Silver from a Novel Implant Coating Using High-Energy Focused Shock Waves.Pharmaceutics · 2023Article
- Rifampicin restores extracellular organic matrix formation and mineralization of osteoblasts after intracellularBone & joint research · 2022Article
- Pathophysiology of Demineralization, Part II: Enamel White Spots, Cavitated Caries, and Bone Infection.Current osteoporosis reports · 2022Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsBiofilm formation is one of the primary reasons for the difficulty in treating implant-related infections (IRIs). Focused high-energy extracorporeal shockwave therapy (fhESWT), which is a treatment modality for fracture nonunions, has been shown to have a direct antibacterial effect on planktonic bacteria. The goal of the present study was to investigate the effect of fhESWT on
methods
resultsThe application of fhESWT led to a ten-fold reduction in bacterial counts on the metal discs for all impulse numbers compared to the control (p < 0.001). Increasing the number of impulses did not further reduce bacterial counts in the absence of antibiotics (all p > 0.289). Antibiotics alone reduced the number of bacteria on the discs; however, the combined application of the fhESWT and antibiotic administration further reduced the bacterial count compared to the antibiotic treatment only (p = 0.032).
conclusionThe use of fhESWT significantly reduced the colony-forming unit (CFU) count of a
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.