ArticleAllergy, asthma & immunology research2021
Sex Differences in Severe Asthma: Results From Severe Asthma Network in Italy-SANI.
Article in Allergy, asthma & immunology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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Who cites it
32 citing papers in PubMed, 60 citations in OpenAlex.
- Real-World Effectiveness of Dupilumab in Severe Uncontrolled Asthma: Clinical Remission on Treatment, Predictors of Complete Response and Impact on Type-2 Comorbidities.Journal of clinical medicine · 2026Article
- Severe Asthma in Women: Clinical Characteristics and Pharmacological Implications for Tailored Management.Respiration; international review of thoracic diseases · 2026Article
- Sexual Dimorphism in Allergic and Mast Cell-Associated Diseases.Clinical reviews in allergy & immunology · 2026Review
- Real-World Effectiveness of Tezepelumab in Severe Asthma: A Comparative Analysis of High and Low T2 Phenotypes.Journal of personalized medicine · 2026Article
- Longitudinal observation of severe asthma comorbidities and oral corticosteroids use from SANI and ISAR registries.The World Allergy Organization journal · 2026Article
- Age-sex differences in the global burden of asthma and risk factors, 1990-2021: results from the global burden of disease study 2021.BMC pulmonary medicine · 2026Article
- A Multidimensional approach to Severe Asthma Management: the need for Pulmonary Rehabilitation among candidates for Biologic Therapy.Frontiers in medicine · 2026Article
- Sex, hormones, and lung health.Physiological reviews · 2026Review
- Role of body anthropometry in severe asthmatic patients: Evidences from the Severe Asthma Network in Italy (SANI) registry.The World Allergy Organization journal · 2025Article
- Targeting IL-13 and IL-4 in Asthma: Therapeutic Implications on Airway Remodeling in Severe Asthma.Clinical reviews in allergy & immunology · 2025Review
- Global burden of asthma attributable to high body mass index in older adults 1990-2021 and prediction to 2050: An analysis of Global Burden of Disease Study 2021.The World Allergy Organization journal · 2025Article
- Sex differences in asthma: omics evidence and future directions.Frontiers in genetics · 2025Review
- Demographic and regional analysis of 22 years of mortality data from coexisting asthma and cardiovascular disease in the United States.Proceedings (Baylor University. Medical Center) · 2025Article
- Long-term multicenter comparison shows equivalent efficacy of monoclonal antibodies in severe asthma therapy.BMC pulmonary medicine · 2024Article
- Severe asthma care trajectories: the French RAMSES cohort.ERJ open research · 2024Article
- Chinese expert consensus on the diagnosis, treatment, and management of asthma in women across life.Journal of thoracic disease · 2024Review
- Phenotypic characteristics of asthma and morbidity are associated with distinct longitudinal changes in L-arginine metabolism.BMJ open respiratory research · 2023Article
- What bothers severe asthma patients most? A paired patient-clinician study across seven European countries.ERJ open research · 2023Article
- The "Asthma-Polycystic Ovary Overlap Syndrome" and the Therapeutic Role of Myo-Inositol.International journal of molecular sciences · 2023Review
- Real-World Experience on the Use of Mepolizumab from the Severe Asthma Registry of the German Asthma Net (MepoGAN-Study).Journal of asthma and allergy · 2023Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
Abstract
purposeAfter adolescence, asthma is more frequent in females than in males due to different hormonal, immunologic, and occupational/environmental factors. The higher prevalence and severity of the disease in females have already been reported in international registries. The aim of this study was to explore the difference in terms of clinical, functional, and biological characteristics between male and female patients with severe asthma in a real-life, registry-based setting.
methodsBaseline data from the Severe Asthma Network in Italy registry were analyzed in 1,123 patients with severe asthma, according to sex.
resultsAlmost 2/3 of severe asthmatics were female. Late-onset asthma, obesity and gastro-esophageal reflux were more frequent in females than in males, while previous smoking habits and nasal polyposis were more frequent in males. Females had poor asthma control and a higher number of severe exacerbations leading to hospitalization, in comparison to males. Biomarkers of type 2 inflammation (blood eosinophil, exhaled nitric oxide, and serum immunoglobulin E levels) were significantly higher in males than in females. The type 2 profile (defined by a combination of these 3 biomarkers) was significantly more frequent in males than in females. In multivariate analysis, late-onset asthma and a normal body mass index were only independent variables associated with the type 2 profile, while male sex and age showed only a trend toward the association with the type 2 profile.
conclusionsSignificant differences may be observed between male and female patients with severe asthma, influencing the asthma pheno-endotyping in both sexes.
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