Evidence map›Paper›PMID 33474842›Full record

ReviewThe world journal of men's health2021

Anything New about Paternal Contribution to Reproductive Outcomes? A Review of the Evidence.

Caterina Montagnoli, Stefania Ruggeri, Giulia Cinelli, Alberto E Tozzi, Chiara Bovo, Renata Bortolus, Giovanni Zanconato

Abstract readReview
In one paragraph

Review in The world journal of men's health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Iranian men's Perception toward Preconception Care: A Qualitative Content Analysis.International journal of community based nursing and midwifery · 2026
    Article
  4. Article
  5. Article
  6. Observational
  7. Review
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Caterina MontagnoliDepartment of Medical Direction, Verona University Hospital, Verona, Italy.ORCID https://orcid.org/0000-0003-1819-8273
Stefania RuggeriResearch Centre for Food and Nutrition-CREA, Rome, Italy.ORCID https://orcid.org/0000-0003-0032-7567
Giulia CinelliPredictive and Preventive Medicine Research Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.ORCID https://orcid.org/0000-0001-6985-3982
Alberto E TozziPredictive and Preventive Medicine Research Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. albertoeugenio.tozzi@opbg.net.ORCID https://orcid.org/0000-0002-6884-984X
Chiara BovoDepartment of Medical Direction, Verona University Hospital, Verona, Italy.ORCID https://orcid.org/0000-0003-2081-2009
Renata BortolusDirectorate General for Preventive Health - Office 9, Ministry of Health, Rome, Italy.ORCID https://orcid.org/0000-0003-3857-4133
Giovanni ZanconatoDepartment of Surgery, Odontostomatology and Maternal and Child Health, University of Verona, Verona, Italy.ORCID https://orcid.org/0000-0003-3717-6205

Funding

Italian Ministry of Health-CCM
6 · The paper itself

Abstract

Paternal health and behavioral lifestyles affect reproductive and neonatal outcomes and yet the magnitude of these effects remain underestimated. Even though these impacts have been formally recognized as a central aspect of reproductive health, health care services in Europe often neglect the involvement of fathers in their reproductive programs. Following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines for systematic reviews, a literature search was carried out to assess the possible impact of paternal health on reproductive outcomes. The comprehensive strategy included cohort studies and meta-analysis available on PubMed, Web of Science, CINAHL, and Google scholar. Cross-referencing of bibliographies of the selected papers ensured wider study capture. Paternal factors were grouped into two categories respectively identified with the terms "Biological Paternal Factors" and "Lifestyle Paternal Factors". Advanced age may impair male fertility and affect early pregnancy stages. Increased body mass index, smoking, alcohol and recreational drugs, all alter seminal fluid parameters. Hazardous alcohol use correlates with low birthweight in pregnancy and harmful behavioral lifestyles have been linked to congenital heart defects, metabolic and neurodevelopmental disorders in the offspring. Measures targeting paternal health and lifestyle within the first 1,000 days' timeframe need to be implemented in couples undergoing reproductive decisions. Health professionals, as well as future fathers, must be aware of the benefits for the offspring associated with correct paternal behaviors. More research is needed to build guidelines and to implement specific programs aiming at reproductive health promotion.

Indexed as

FertilityLife styleLong term adverse effectsMaternal healthPaternal exposure

Identifiers

PMID33474842
PMCPMC8443996

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.