Evidence map›Paper›PMID 33474694›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2022

Performance of cardiac PET/CT with and without phase analysis for detection of scar in cardiac sarcoidosis: Comparison to cardiac magnetic resonance imaging.

Mohamed Y Elwazir, Jared G Bird, Omar F AbouEzzeddine, Panithaya Chareonthaitawee, Lori A Blauwet, Jeremy D Collins, Raymond J Gibbons, Martin Rodriguez-Porcel, Hanan M Kamal, Ahmed T Abdellah and 1 more

Abstract read
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In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Probing the shadows of myocardial scar: Can PET MPI see what MRI sees?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2025
    Article
  2. Added value gated PET with phase analysis for the detection of scar burden and prognostication in cardiac sarcoidosis?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Mohamed Y ElwazirDepartment of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Jared G BirdDepartment of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Omar F AbouEzzeddineDepartment of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Panithaya ChareonthaitaweeDepartment of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Lori A BlauwetDepartment of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Jeremy D CollinsDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Raymond J GibbonsDepartment of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Martin Rodriguez-PorcelDepartment of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Hanan M KamalDepartment of Cardiology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Ahmed T AbdellahDepartment of Cardiology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
John P BoisDepartment of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. bois.john@mayo.edu.
Mayo Clinic · USSuez Canal University · EGMayo Clinic in Arizona · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe presence of myocardial scar in CS patients results in poor prognosis and worse outcomes.

methods176 patients who underwent cardiac magnetic resonance (CMR) and N-13 ammonia/

resultsSensitivity of PET/CT for scar detection was 45.3% (specificity 88.9%). Addition of PET-derived LV volumes and function in a logistic regression model improved sensitivity to 57.0% (specificity: 80.0%, AUC 0.72). Addition of phase analysis maximum segmental onset of myocardial contraction > 61 improved AUC to 0.75, correctly relabeling 16.3% of patients as scar (net reclassification index 8.2%).

conclusionSensitivity of gated PET MPI alone for scar detection in CS is suboptimal. Adding PET-derived volumes/function and phase analysis data results in improved detection and characterization of scar.

Indexed as

MyocarditisSarcoidosisCicatrixContrast MediaFluorodeoxyglucose F18GadoliniumHumansMagnetic Resonance ImagingPositron Emission Tomography Computed TomographyContrast MediaFluorodeoxyglucose F18GadoliniumInflammationMetabolicMPIMRIPETSarcoid heard disease

Identifiers

PMID33474694
OpenAlexW3121980494

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.