ArticleCardiovascular and interventional radiology2021
Genicular artEry embolizatioN in patiEnts with oSteoarthrItiS of the Knee (GENESIS) Using Permanent Microspheres: Interim Analysis.
Article in Cardiovascular and interventional radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 58 papers, 1 of them a synthesis that pooled it.
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Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it, 130 citations in OpenAlex.
- Knee pain improvement after genicular artery embolization for the management of knee osteoarthritis: an updated systematic review and meta-analysis of 21 studies.Radiologie (Heidelberg, Germany) · 2024Pooled it
- Genicular Artery Embolization Using Imipenem/Cilastatin vs. Microsphere for Knee Osteoarthritis (GAUCHO). 12-Month Clinical Results of a Single-blind Randomized Controlled Trial.Cardiovascular and interventional radiology · 2026Trial
- Genicular artery embolisation versus sham embolisation for symptomatic osteoarthritis of the knee: a randomised controlled trial.BMJ open · 2024Trial
- Genicular Artery Embolization for Chronic Knee Pain: Expert Consensus Recommendations on Indications, Technique and Clinical Care Using a Delphi Process.Cardiovascular and interventional radiology · 2026Article
- Genicular artery embolization for refractory pain after knee arthroplasty: clinical outcomes from a retrospective pilot study.CVIR endovascular · 2026Article
- Genicular artery embolization as a minimally invasive treatment for knee osteoarthritis: systematic review and meta-analysis.Skeletal radiology · 2026Article
- Genicular Artery Embolization (GAE) for the Treatment of Advanced Knee Osteoarthritis in Selected Nonoperative Patients: A Pilot Study at 6 Months Follow-Up.Journal of clinical medicine · 2026Article
- Genicular Artery Embolization for Chronic Exudative Knee Synovitis: Prospective 6-Month Clinical and Functional Outcomes.Journal of clinical medicine · 2026Article
- Repeated Genicular Artery Embolization Using Permanent Microspheres for Severe Osteoarthritis and Postsurgical Pain.Cardiovascular and interventional radiology · 2026Observational
- Segmentation of blush size guides embolic endpoints in genicular artery embolization.European radiology · 2026Article
- HipE Study-Hip Embolization for Pain Control in Hip Osteoarthritis and Greater Trochanteric Pain Syndrome: 12 Months Follow-Up.Cardiovascular and interventional radiology · 2026Article
- Standardized angiographic workflow and technique for genicular artery embolization.CVIR endovascular · 2026Article
- Genicular Artery Embolization for Knee Osteoarthritis: An Interventional Radiology Perspective on Pathophysiology, Imaging Biomarkers and Procedural Strategy.Diagnostics (Basel, Switzerland) · 2026Review
- Genicular artery embolization for treating knee osteoarthritis - an overview of the evidence.Pain management · 2026Review
- Potential Predictors of Pain and Stiffness Response Following Genicular Artery Embolization for Knee Osteoarthritis.Journal of clinical medicine · 2026Article
- Genicular Artery Embolization Using Resorbable Gelatin Microspheres for Refractory Knee Pain: Technique, Safety and Clinical Outcome.Cardiovascular and interventional radiology · 2026Observational
- Early intervention in knee osteoarthritis with genicular artery embolization is associated with improved clinical outcomes.European radiology · 2025Article
- Road to Genicular Artery Embolization: Importance of the Anastomotic Network.Cardiovascular and interventional radiology · 2025Article
- Machine Learning and MRI-Based Whole-Organ Magnetic Resonance Imaging Score (WORMS): A Novel Approach to Enhancing Genicular Artery Embolization Outcomes in Knee Osteoarthritis.Cardiovascular and interventional radiology · 2025Article
- Large language models for patient education prior to interventional radiology procedures: a comparative study.CVIR endovascular · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePlanned interim analysis of GENESIS; a prospective pilot study investigating the role of genicular artery embolization (GAE) in patients with mild to moderate osteoarthritis of the knee using permanent microspheres.
methodsThirty-eight patients, median age = 60 (45-83), attended for GAE using 100-300 μm permanent microspheres. All patients had mild to moderate knee OA, resistant to conservative treatments over 6 months. Knee MRI was performed at baseline, and 12 months, enabling semi-quantitative analysis using Whole-Organ Magnetic Resonance Imaging Score (WORMS). Knee Injury and Osteoarthritis Outcome Score (KOOS) and visual analogue scale (VAS) (0-100 mm) were completed at baseline, 6 weeks, 3 months (n = 32), and 1-year (n = 16). Adverse events were recorded prospectively.
resultsTechnical success of accessing and embolizing the target genicular arteries was 84%. Six patients were not embolized: four due to a presumed risk of non-target embolization, and two due to a lack of hyperaemic target. Mean VAS improved from 60 (SD = 20, 95% CI 53-66) at baseline to 36 (SD = 24, 95% CI 28-44) at 3 months (p < 0.001) and 45 (SD = 30, 95% CI 30-60) at 1-year (p < 0.05). All KOOS subscales showed a significant improvement at 6-weeks, 3-months, and 1-year follow-up, except function in daily living, which reached borderline significance (p = 0.06) at 1-year. Four patients experienced mild self-limiting skin discoloration over the embolized territory. One patient experienced a small self-limiting groin haematoma. WORMS scores at 1-year follow-up showed significant improvement in synovitis (p < 0.05). There were no cases of osteonecrosis.
conclusionGAE using permanent microspheres in patients with mild to moderate knee OA is safe, with potential efficacy at early follow-up.
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