ArticleiScience2021
The downregulation of IL-18R defines bona fide kidney-resident CD8
Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Interleukin-18 armours antitumour immune effectors.Nature reviews. Immunology · 2026Review
- Article
- Evolving role of CD8Frontiers in immunology · 2026Review
- The Janus face of tissue-resident memory T cells: dual programming in tumor immune surveillance and autoimmune pathology.Frontiers in immunology · 2026Review
- Distinct transcriptomic signatures in pulmonary tissue resident and vascular resident-like T cells in nonhuman primates.iScience · 2025Article
- Keeping it local: how CD8 TRMs regulate viral and cancer immunity.Frontiers in immunology · 2025Review
- T-bet deficiency and Hic1 induction override TGF-β-dependency in the formation of CD103Cell reports · 2024Article
- Insights into phenotypic and functional CD8Immunological reviews · 2023Review
- Tissue-resident memory T cells in the kidney.Seminars in immunopathology · 2022Review
- TGF-β-dependent lymphoid tissue residency of stem-like T cells limits response to tumor vaccine.Nature communications · 2022Article
- TGF-β promotes stem-like T cells via enforcing their lymphoid tissue retention.The Journal of experimental medicine · 2022Article
- Tissue-resident memory CD8Nature immunology · 2022Article
- Tissue-resident memory T cells in gastrointestinal cancer immunology and immunotherapy: ready for prime time?Journal for immunotherapy of cancer · 2022Review
- Lymphoid tissue residency: A key to understand Tcf-1Frontiers in immunology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
Abstract
Stepwise induction of CD69 and CD103 marks distinct differentiation stages of mucosal Trms. But the majority of non-mucosal Trm lacks CD103 expression. The expression of CD69 alone cannot faithfully define Trm cells in heavily vascularized non-mucosal tissues, such as the kidney. Here, we found that a subset of kidney Trms downregulated IL-18 receptor during differentiation. Via global transcriptional analysis and parabiosis experiments, we have discovered that the downregulation of interleukin-18 receptor (IL-18R) is associated with the establishment of tissue residency. Together with the expression of CD69, IL-18R
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.